| Gene Symbol | MSL3 |
|---|---|
| Entrez Gene | 10943 |
| Alt Symbol | MSL3L1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | male-specific lethal 3 homolog (Drosophila) |
| Other Description | MSL3-like 1|male-specific lethal 3 homolog|male-specific lethal-3 protein-like 1 |
| Swissprots | A8K165 A6NHW8 A6NCU2 B4DUV8 Q8N5Y2 B7Z227 Q9Y5Z8 Q9UG70 |
| Accessions | EAW98799 EAW98800 EAW98801 EAW98802 Q8N5Y2 AF117065 AAD38499 AK000793 AK025642 AK289780 BAF82469 AK294255 BAH11713 AK300814 BAG62470 AK304419 BAG65249 AL050178 CAB43308 AL713667 CAD28473 BC010925 BC017267 BC031210 AAH31210 BI091178 BI560203 CT002798 DA172776 DA788603 DA961602 DB240082 DC395802 DQ891661 ABM82587 DQ894848 ABM85774 XM_005274440 XP_005274497 XM_006724461 XP_006724524 XM_011545442 XP_011543744 XM_011545443 XP_011543745 XM_011545444 XP_011543746 NM_001193270 NP_001180199 NM_001282174 NP_001269103 NM_006800 NP_006791 NM_078628 NP_523352 NM_078629 NP_523353 NM_078630 |
| Function | May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22547026}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Expressed in many tissues including liver, pancreas, heart, lung, kidney, skeletal muscle, brain, and placenta, with highest expression in skeletal muscle and heart. |