| Gene Symbol |
Nprl3
|
| Entrez Gene |
17168
|
| Alt Symbol |
Aag, CGTHBA, HS-26, HS-40, Mare, Phg, Prox1, m(alpha)RE
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nitrogen permease regulator-like 3
|
| Other Description |
-14|alpha globin regulatory element containing|alpha-globin regulatory element-containing gene protein|nitrogen permease regulator 3-like protein|proximal locus to the hemoglobin alpha chain complex
|
| Swissprots |
Q8VIJ8
|
| Accessions |
AAL32369 EDL23760 EDL23761 Q8VIJ8 AK036405 BAC29415 AK036633 BAC29512 AK039600 AK047190 BAC32985 AK081902 BAC38366 AK086378 AK090290 AK154884 AK179291 AK184012 BC064471 AAH64471 BY210864 XM_006514556 XP_006514619 XM_006514558 XP_006514621 XM_011243667 XP_011241969 XR_380960 NM_001284359 NP_001271288 NM_001284360 NP_001271289 NM_181569 NP_853547 NR_104306
|
| Function |
As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC- containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). {ECO:0000250}.
|