Gene Symbol | Nprl3 |
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Entrez Gene | 17168 |
Alt Symbol | Aag, CGTHBA, HS-26, HS-40, Mare, Phg, Prox1, m(alpha)RE |
Species | Mouse |
Gene Type | protein-coding |
Description | nitrogen permease regulator-like 3 |
Other Description | -14|alpha globin regulatory element containing|alpha-globin regulatory element-containing gene protein|nitrogen permease regulator 3-like protein|proximal locus to the hemoglobin alpha chain complex |
Swissprots | Q8VIJ8 |
Accessions | AAL32369 EDL23760 EDL23761 Q8VIJ8 AK036405 BAC29415 AK036633 BAC29512 AK039600 AK047190 BAC32985 AK081902 BAC38366 AK086378 AK090290 AK154884 AK179291 AK184012 BC064471 AAH64471 BY210864 XM_006514556 XP_006514619 XM_006514558 XP_006514621 XM_011243667 XP_011241969 XR_380960 NM_001284359 NP_001271288 NM_001284360 NP_001271289 NM_181569 NP_853547 NR_104306 |
Function | As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC- containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). {ECO:0000250}. |
NPRL3 siRNA (m) - sc-149274 from Santa Cruz Biotechnology
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NPRL3 shRNA Plasmid (m) - sc-149274-SH from Santa Cruz Biotechnology
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NPRL3 shRNA (m) Lentiviral Particles - sc-149274-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU011831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN36629 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36629 from Sigma-Aldrich
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NPRL3 siRNA (Mouse) - CRM2458 from Cohesion Biosciences
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shRNA set against Mouse NPRL3 (NM_181569.2) - SHH354440 from Creative biogene
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shRNA set against Mouse Mare(NM_181569.2) - SHH177383 from Creative biogene
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NPRL3 shRNA Plasmid (Mouse) - CHM2458 from Cohesion Biosciences
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NPRL3 miRNA 3'UTR clone - MiUTR1M-06956 from Creative biogene
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