| Gene Symbol |
GUF1
|
| Entrez Gene |
60558
|
| Alt Symbol |
EF-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GUF1 GTPase homolog (S. cerevisiae)
|
| Other Description |
EF-4|GTP-binding protein GUF1 homolog|GTPase GUF1|GTPase of unknown function 1|elongation factor 4 homolog|ribosomal back-translocase|translation factor GUF1, mitochondrial
|
| Swissprots |
Q5XKM8 Q8N442 Q9H710 Q9H8U4
|
| Accessions |
EAW93017 EAW93018 Q8N442 AK001607 AK023282 BAB14507 AK025248 BAB15090 AK225314 AK308667 BC012338 BC036768 AAH36768 DA997676 XM_005248122 XP_005248179 XM_011513732 XP_011512034 XM_011513733 XP_011512035 XM_011513734 XP_011512036 NM_021927 NP_068746
|
| Function |
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. {ECO:0000255|HAMAP-Rule:MF_03137}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03137}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03137}; Matrix side {ECO:0000255|HAMAP- Rule:MF_03137}.
|
![Western Blot: GUF1 Overexpression Lysate (Adult Normal) [NBP2-06509] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GUF1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6035_GUF1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06509-img0001.jpg)