Gene Symbol | GUF1 |
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Entrez Gene | 60558 |
Alt Symbol | EF-4 |
Species | Human |
Gene Type | protein-coding |
Description | GUF1 GTPase homolog (S. cerevisiae) |
Other Description | EF-4|GTP-binding protein GUF1 homolog|GTPase GUF1|GTPase of unknown function 1|elongation factor 4 homolog|ribosomal back-translocase|translation factor GUF1, mitochondrial |
Swissprots | Q5XKM8 Q8N442 Q9H710 Q9H8U4 |
Accessions | EAW93017 EAW93018 Q8N442 AK001607 AK023282 BAB14507 AK025248 BAB15090 AK225314 AK308667 BC012338 BC036768 AAH36768 DA997676 XM_005248122 XP_005248179 XM_011513732 XP_011512034 XM_011513733 XP_011512035 XM_011513734 XP_011512036 NM_021927 NP_068746 |
Function | Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. {ECO:0000255|HAMAP-Rule:MF_03137}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03137}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03137}; Matrix side {ECO:0000255|HAMAP- Rule:MF_03137}. |
GUF1 CRISPR/Cas9 KO Plasmid (h) - sc-407827 from Santa Cruz Biotechnology
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GUF1 HDR Plasmid (h) - sc-407827-HDR from Santa Cruz Biotechnology
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GUF1 Double Nickase Plasmid (h) - sc-407827-NIC from Santa Cruz Biotechnology
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GUF1 Double Nickase Plasmid (h2) - sc-407827-NIC-2 from Santa Cruz Biotechnology
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GUF1 CRISPR Activation Plasmid (h) - sc-407827-ACT from Santa Cruz Biotechnology
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GUF1 CRISPR Activation Plasmid (h2) - sc-407827-ACT-2 from Santa Cruz Biotechnology
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GUF1 Lentiviral Activation Particles (h) - sc-407827-LAC from Santa Cruz Biotechnology
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GUF1 Lentiviral Activation Particles (h2) - sc-407827-LAC-2 from Santa Cruz Biotechnology
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GUF1 siRNA (h) - sc-89135 from Santa Cruz Biotechnology
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GUF1 shRNA Plasmid (h) - sc-89135-SH from Santa Cruz Biotechnology
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GUF1 shRNA (h) Lentiviral Particles - sc-89135-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU014401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9805 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9805 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04388 from Sigma-Aldrich
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GUF1 siRNA (Human) - CRJ1815 from Cohesion Biosciences
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GUF1 RNAi - H00060558-R01 from Novus Biologicals
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GUF1 - MBS827075 from MyBioSource
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shRNA set against Human GUF1 (NM_021927.2) - SHH309422 from Creative biogene
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shRNA set against Human GUF1(NM_021927.2) - SHH110603 from Creative biogene
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Human GUF1 siRNA - orb272316 from Biorbyt
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GUF1 shRNA Plasmid (Human) - CHJ1815 from Cohesion Biosciences
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GUF1 miRNA 3'UTR clone - MiUTR1H-04336 from Creative biogene
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