OPRL1

Gene Symbol OPRL1
Entrez Gene 4987
Alt Symbol KOR-3, NOCIR, OOR, ORL1
Species Human
Gene Type protein-coding
Description opiate receptor-like 1
Other Description kappa-type 3 opioid receptor|kappa3-related opioid receptor|nociceptin receptor|orphanin FQ receptor
Swissprots Q8TD34 P41146 Q8WYH9 Q9H4K4
Accessions AAG42351 EAW75162 EAW75163 P41146 AF115266 AAO13224 AF126470 AAL54890 AF285093 AAG42691 AF285094 AAG42692 AF285095 AAG42693 AF348323 AAK11714 AK308203 AW451157 AY268428 AAP23195 BC038433 AAH38433 CN267465 CR542061 CAG46858 CR542082 CAG46879 DQ893206 ABM84132 DQ893207 ABM84133 EU176792 ABW03593 L40949 AAA96251 U30185 AAA84913 X77130 CAA54386 XM_011528828 XP_011527130 XM_011528829 XP_011527131 XM_011528830 XP_011527132 NM_000913 NP_000904 NM_001200019 NP_001186948 NM_182647 NP_872588
Function G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.
Tissue Specificity Detected in blood leukocytes. {ECO:0000269|PubMed:7500847}.
Top Pathways Neuroactive ligand-receptor interaction

KOR-3 (A-18) - sc-9760 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

KOR-3 (H-85) - sc-15309 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
KOR-3 (H-85): sc-15309. Western blot analysis of KOR-3 expression in Raji (A), C6 (B) and SK-N-MC (C) whole cell lysates.

KOR-3 (N-19) - sc-9759 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Nociceptin receptor antibody - ab66219 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Ab66219 staining of Oprl1 in rat brain (singulate cortex) by immunocytochemistry.

Anti-Nociceptin receptor antibody - ab183080 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Nociceptin receptor antibody (ab183080) at 1/900 dilution + lysate at 40 µgSecondaryGoat anti Rabbit IgG - H&L (HRP) at 1/10000 dilutiondeveloped using the ECL technique

Anti-OPRL1 / ORL1 Antibody (clone 2A11) - LS-C197824 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A11
Detection limit for recombinant GST tagged OPRL1 is approximately 3 ng/ml as a capture antibody.

Anti-OPRL1 / ORL1 Antibody (aa231-280) - LS-C135554 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OPRL1 antibody LS-C135554 Western blot of HepG2 cell lysate.

Anti-OPRL1 / ORL1 Antibody - LS-C335294 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using OPRL1 antibody.

Anti-OPRL1 / ORL1 Antibody IHC-plus™ - LS-B10214 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-OPRL1 / ORL1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10214 dilution 1:100.

Anti-OPRL1 / ORL1 Antibody (aa1-370) - LS-C131075 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ORL1/OPRL1 Antibody - NBP2-21065 from Novus Biologicals

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Oprl1 Antibody [NBP2-21065] - ORL1 (green) staining in rat brain (singulate cortex). DAPI was used to counterstain cell nuclei (blue color).

ORL1/OPRL1 Antibody - NBP1-87237 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: Oprl1 Antibody [NBP1-87237] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY416784)

ORL1/OPRL1 Antibody - H00004987-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: ORL1/OPRL1 Antibody [H00004987-D01P] - Analysis of OPRL1 expression in transfected 293T cell line by OPRL1 polyclonal antibody.Lane 1: OPRL1 transfected lysate(40.70 KDa).Lane 2: Non-transfected lysate.

ORL1/OPRL1 Antibody (2A11) - H00004987-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A11

Monoclonal Anti-OPRL1 antibody produced in mouse - WH0004987M2 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A11
<B>Sandwich ELISA</B><BR/>Monoclonal Anti-OPRL1, <B>Cat. No. WH0004987M2</B>: the detection limit for recombinant GST tagged OPRL1 is approximately 3ng/mL.

Anti-OPRL1 antibody produced in rabbit - SAB2107411 from Sigma-Aldrich

Prices $341.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-OPRL1: <B>Cat. No. SAB2107411</B>: Western blot analysis of OPRL1 with OPRL1 (opiate receptor-like 1) antibody against the middle region of OPRL1 (50 μg) antibody at 1.0 μg/mL.

OPRL1 antibody - middle region (ARP59570_P050) - ARP59570_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OPRL1-Antibody-monoclonal-M02 - AT3151a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A11
Detection limit for recombinant GST tagged OPRL1 is approximately 3ng/ml as a capture antibody.

Nociceptin Receptor antibody - GTX37594 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-Nociceptin Receptor antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX37594

Nociceptin Receptor antibody - orb11143 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
IHC-Fr of mouse hippocampus forzen section using Nociceptin Receptor antibody.

Nociceptin Receptor antibody (PE-Cy5.5) - orb130555 from Biorbyt

Prices $425.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal

OPRL1 Polyclonal Antibody - A3113 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using OPRL1 antibody.

OPRL1 antibody - orb107595 from Biorbyt

Prices $417.00, $536.00
Sizes 50 μl, 100 μl
Host Rabbit
Clonality Polyclonal
Western blot analysis of Gel: 10%SDS-PAGE(40ug per lane lysate) at:1:900 dilution using OPRL1 antibody

OPRL1 antibody - 70R-19046 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

OPRL1 antibody - 70R-9817 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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