OPRL1

Gene Symbol OPRL1
Entrez Gene 4987
Alt Symbol KOR-3, NOCIR, OOR, ORL1
Species Human
Gene Type protein-coding
Description opiate receptor-like 1
Other Description kappa-type 3 opioid receptor|kappa3-related opioid receptor|nociceptin receptor|orphanin FQ receptor
Swissprots Q8TD34 P41146 Q8WYH9 Q9H4K4
Accessions AAG42351 EAW75162 EAW75163 P41146 AF115266 AAO13224 AF126470 AAL54890 AF285093 AAG42691 AF285094 AAG42692 AF285095 AAG42693 AF348323 AAK11714 AK308203 AW451157 AY268428 AAP23195 BC038433 AAH38433 CN267465 CR542061 CAG46858 CR542082 CAG46879 DQ893206 ABM84132 DQ893207 ABM84133 EU176792 ABW03593 L40949 AAA96251 U30185 AAA84913 X77130 CAA54386 XM_011528828 XP_011527130 XM_011528829 XP_011527131 XM_011528830 XP_011527132 NM_000913 NP_000904 NM_001200019 NP_001186948 NM_182647 NP_872588
Function G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.
Tissue Specificity Detected in blood leukocytes. {ECO:0000269|PubMed:7500847}.
Top Pathways Neuroactive ligand-receptor interaction

KOR-3 CRISPR/Cas9 KO Plasmid (h) - sc-402526 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KOR-3 HDR Plasmid (h) - sc-402526-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KOR-3 Double Nickase Plasmid (h) - sc-402526-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KOR-3 Double Nickase Plasmid (h2) - sc-402526-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KOR-3 CRISPR Activation Plasmid (h) - sc-402526-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KOR-3 CRISPR Activation Plasmid (h2) - sc-402526-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KOR-3 Lentiviral Activation Particles (h) - sc-402526-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KOR-3 Lentiviral Activation Particles (h2) - sc-402526-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KOR-3 siRNA (h) - sc-42150 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KOR-3 shRNA Plasmid (h) - sc-42150-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KOR-3 shRNA (h) Lentiviral Particles - sc-42150-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ORL1/OPRL1 RNAi - H00004987-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU060761 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15746 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15746 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10547 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10547

OPRL1 siRNA (Human) - CRH3308 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ORL1/OPRL1 RNAi - H00004987-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

KOR-3 CRISPR/Cas9 KO Plasmid (h2) - sc-402526-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KOR-3 HDR Plasmid (h2) - sc-402526-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human OPRL1 (NM_000913.4) - SHH366732 from Creative biogene

Category siRNA
Species Reactivities Human

Human OPRL1 siRNA - orb263810 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

OPRL1 shRNA Plasmid (Human) - CHH3308 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

OPRL1 miRNA 3'UTR clone - MiUTR3H-05075 from Creative biogene

Species Reactivities Human

OPRL1 miRNA 3'UTR clone - MiUTR3H-05076 from Creative biogene

Species Reactivities Human
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