| Gene Symbol |
PTPRB
|
| Entrez Gene |
5787
|
| Alt Symbol |
HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, receptor type, B
|
| Other Description |
VE-PTP|protein tyrosine phosphatase, receptor type, beta polypeptide|receptor-type tyrosine-protein phosphatase beta|vascular endothelial protein tyrosine phosphatase
|
| Swissprots |
B7ZKS8 F5H3G6 P23467 Q14D85 Q3MIV7 C9JX87 B7ZKT0
|
| Accessions |
CCF76937 CCF76938 EAW97253 EAW97254 P23467 AK023720 AK096717 AK097371 AK126121 BAC86450 AK128562 BAC87502 BC043182 BC051329 AAH51329 BC101679 AAI01680 BC113463 AAI13464 BC143356 AAI43357 BC143360 AAI43361 BE042873 BX647238 CAH10386 BX648245 BX648771 CAE46198 CR749546 CAH18347 DA883934 DN999550 X54131 CAA38066 XM_006719528 XP_006719591 XM_006719529 XP_006719592 XM_011538614 XP_011536916 XR_944651 NM_001109754 NP_001103224 NM_001206971 NP_001193900 NM_001206972 NP_001193901 NM_002837 NP_002828
|
| Function |
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Top Pathways |
Adherens junction
|