PTPRB

Gene Symbol	PTPRB
Entrez Gene	5787
Alt Symbol	HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, receptor type, B
Other Description	VE-PTP|protein tyrosine phosphatase, receptor type, beta polypeptide|receptor-type tyrosine-protein phosphatase beta|vascular endothelial protein tyrosine phosphatase
Swissprots	B7ZKS8 F5H3G6 P23467 Q14D85 Q3MIV7 C9JX87 B7ZKT0
Accessions	CCF76937 CCF76938 EAW97253 EAW97254 P23467 AK023720 AK096717 AK097371 AK126121 BAC86450 AK128562 BAC87502 BC043182 BC051329 AAH51329 BC101679 AAI01680 BC113463 AAI13464 BC143356 AAI43357 BC143360 AAI43361 BE042873 BX647238 CAH10386 BX648245 BX648771 CAE46198 CR749546 CAH18347 DA883934 DN999550 X54131 CAA38066 XM_006719528 XP_006719591 XM_006719529 XP_006719592 XM_011538614 XP_011536916 XR_944651 NM_001109754 NP_001103224 NM_001206971 NP_001193900 NM_001206972 NP_001193901 NM_002837 NP_002828
Function	Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Top Pathways	Adherens junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PTPRB protein fragment - ab42583 from Abcam Category Protein Prices $284.00 Sizes 20 µg Source E. coli Species Human

HPTPB / PTPRB Antibody Blocking Peptide - LS-E27407 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPRB blocking peptide - GTX88020-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Pig, Rat, Bovine

Human PTPRB protein - orb246420 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PTPRB protein - orb246777 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PTPRB Protein - abx068770 from Abbexa Category Protein Source E.coli Species Human

PTPRB Peptide - AC21-2231-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PTPRB Peptide - 42-804P from ProSci Category Peptide

PTPRB fusion protein - ag10090 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PTPbeta, Active Human Recombinant Protein - GWB-PSFF36 from Genway Biotech Category Protein Prices $353.00 Sizes 20 µg Species Human

Recombinant Human PTPRB, GST-tagged - PTPRB-1859H from Creative Biomart Category Protein Source E.coli.

Recombinant Protein Tyrosine Phosphatase Receptor Type B (PTPRB) - RPB048Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Protein Tyrosine Phosphatase Receptor Type B (PTPRB) - RPB048Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Protein Tyrosine Phosphatase Receptor Type B (PTPRB) - RPB048Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

PTPβ Protein, 10000 units - 14-350 from EMD Millipore Category Protein Source expressed in E. coli

Recombinant Protein Tyrosine Phosphatase Receptor Type B (PTPRB) - RPB048Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Receptor-type tyrosine-protein phosphatase beta(PTPRB) ,partia - CSB-EP019048HU CSB-BP019048HU CSB-MP019048HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Receptor-type tyrosine-protein phosphatase beta(PTPRB) ,partial - CSB-YP019048HU from Cusabio Category Protein Source Yeast Species Human

PTPRB Protein - abx164031 from Abbexa Category Protein Species Human, Mouse

PTPRB (transcript variant 1) - TP326479 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PTPRB, Peptide - MBS427351 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat, Pig, Dog, Bovine

Recombinant Human PTPRB Active - PTP042A from Cell Science Prices $399.00 Sizes 20 μg Species Human

PTPbeta-Antibody-C-term-Blocking-Peptide - BP8413a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTPRB Peptide, Human - M34GP12713H from Creative Peptides Category Peptide Source Synthetic. Species Human

PTPRB Recombinant Protein (OPCA01808) - OPCA01808 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Search more