| Gene Symbol | CAV2 |
|---|---|
| Entrez Gene | 858 |
| Alt Symbol | CAV |
| Species | Human |
| Gene Type | protein-coding |
| Description | caveolin 2 |
| Other Description | caveolae protein, 20-kD|caveolin 2 isoform a and b|caveolin-2 |
| Swissprots | Q9UGM7 A4D0U2 P51636 |
| Accessions | CAB36907 CAB63653 CAB65090 EAL24361 EAL24362 EAW83499 EAW83500 EAW83501 EAW83502 P51636 AA878149 AA883287 AB451285 BAG70099 AB451417 BAG70231 AF035752 AAB88492 AI762868 AK024513 AK310786 AK311964 BAG34904 AM393815 CAL38690 AV650449 AW022298 AY353255 AAQ57600 BC005256 AAH05256 BM542127 BM762545 BT007051 AAP35700 BX350116 CR407685 CAG28613 DA882274 DQ656068 NM_001206747 NP_001193676 NM_001206748 NP_001193677 NM_001233 NP_001224 NM_198212 NP_937855 |
| Function | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. {ECO:0000250}. |
| Tissue Specificity | Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. {ECO:0000269|PubMed:9361015}. |
| Top Pathways | Focal adhesion, Endocytosis, Bacterial invasion of epithelial cells, Proteoglycans in cancer |