CAV2

Gene Symbol	CAV2
Entrez Gene	858
Alt Symbol	CAV
Species	Human
Gene Type	protein-coding
Description	caveolin 2
Other Description	caveolae protein, 20-kD|caveolin 2 isoform a and b|caveolin-2
Swissprots	Q9UGM7 A4D0U2 P51636
Accessions	CAB36907 CAB63653 CAB65090 EAL24361 EAL24362 EAW83499 EAW83500 EAW83501 EAW83502 P51636 AA878149 AA883287 AB451285 BAG70099 AB451417 BAG70231 AF035752 AAB88492 AI762868 AK024513 AK310786 AK311964 BAG34904 AM393815 CAL38690 AV650449 AW022298 AY353255 AAQ57600 BC005256 AAH05256 BM542127 BM762545 BT007051 AAP35700 BX350116 CR407685 CAG28613 DA882274 DQ656068 NM_001206747 NP_001193676 NM_001206748 NP_001193677 NM_001233 NP_001224 NM_198212 NP_937855
Function	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. {ECO:0000250}.
Tissue Specificity	Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. {ECO:0000269|PubMed:9361015}.
Top Pathways	Focal adhesion, Endocytosis, Bacterial invasion of epithelial cells, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Caveolin-2 peptide - ab4929 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Mouse

Caveolin-2 peptide - ab94548 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Caveolin-2 full length protein - ab114515 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Mouse Caveolin-2 peptide - ab4962 from Abcam Category Peptide Species Mouse

CAV2 / Caveolin 2 Antibody Blocking Peptide - LS-E10493 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CAV2 / Caveolin 2 Antibody Blocking Peptide - LS-E9696 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Caveolin-2 Protein - H00000858-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CAV2-Antibody-N-term-Blocking-Peptide - BP8645a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CAV2 Blocking Peptide - 33R-5515 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Caveolin-2 - H00000858-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Caveolin-2 - H00000858-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Caveolin-2 Control Peptide - SP5143CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

CAV2 fusion protein - ag16902 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CAV2 - CAV2-26609TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CAV2, His-tagged - CAV2-10750H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CAV2 - CAV2-508H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Caveolin 2 (CAV2) - RPC952Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Caveolin 2 (CAV2) - RPC952Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Caveolin-2(CAV2) - CSB-YP004572HU CSB-EP004572HU CSB-BP004572HU CSB-MP004572HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Caveolin-2 (transcript variant 1) - TP302703 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Caveolin-2 (full length, N-term HIS tag, transcript variant 2) - TP760372 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Caveolin-2 (CAV2), Recombinant Protein - MBS1324052 from MyBioSource Category Protein Prices $905.00, $905.00, $1,130.00, $1,130.00, $1,340.00, $1,340.00, $1,795.00, $1,795.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Caveolin-2 (CAV2), Recombinant Protein - MBS1286172 from MyBioSource Category Protein Prices $905.00, $905.00, $1,130.00, $1,130.00, $1,340.00, $1,340.00, $1,795.00, $1,795.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

Caveolin-2 (CAV2), Recombinant Protein - MBS1072698 from MyBioSource Category Protein Prices $905.00, $905.00, $1,130.00, $1,130.00, $1,340.00, $1,340.00, $1,795.00, $1,795.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Caveolin-2 (CAV2), Recombinant Protein - MBS1289545 from MyBioSource Category Protein Prices $905.00, $905.00, $1,130.00, $1,130.00, $1,340.00, $1,340.00, $1,795.00, $1,795.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Chimpanzee

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