| Gene Symbol |
NEK6
|
| Entrez Gene |
10783
|
| Alt Symbol |
SID6-1512
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NIMA-related kinase 6
|
| Other Description |
NIMA (never in mitosis gene a)-related kinase 6|never in mitosis A-related kinase 6|nimA-related protein kinase 6|protein kinase SID6-1512|putative serine-threonine protein kinase|serine/threonine-protein kinase Nek6
|
| Swissprots |
Q5TBG3 B7Z2D9 Q96E83 Q6IAR3 Q9HC98 Q9ULX2 Q6FG86 Q5TBG9
|
| Accessions |
EAW87578 EAW87579 EAW87580 EAW87581 Q9HC98 AB026289 BAA85045 AF087909 AAG13417 AJ420460 AK294614 BAH11825 AK313071 BAG35899 BC000101 AAH00101 BC004174 AAH04174 BC004209 AAH04209 BC012761 AAH12761 BM083872 BP219389 BP265230 BP279761 CF994196 CR457091 CAG33372 CR542222 CAG47018 DB350175 XM_005251664 XP_005251721 XM_006716936 XP_006716999 XM_011518155 XP_011516457 NM_001145001 NP_001138473 NM_001166167 NP_001159639 NM_001166168 NP_001159640 NM_001166169 NP_001159641 NM_001166170 NP_001159642 NM_001166171 NP_001159643 NM_014397 NP_055212
|
| Function |
Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. {ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20407017, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.
|
| Tissue Specificity |
Ubiquitous, with highest expression in heart and skeletal muscle. Up-regulated in a variety of malignant cancers, such as breast, colon, lung, and gastric cancers. {ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:20407017}.
|