NEK6

Gene Symbol	NEK6
Entrez Gene	10783
Alt Symbol	SID6-1512
Species	Human
Gene Type	protein-coding
Description	NIMA-related kinase 6
Other Description	NIMA (never in mitosis gene a)-related kinase 6|never in mitosis A-related kinase 6|nimA-related protein kinase 6|protein kinase SID6-1512|putative serine-threonine protein kinase|serine/threonine-protein kinase Nek6
Swissprots	Q5TBG3 B7Z2D9 Q96E83 Q6IAR3 Q9HC98 Q9ULX2 Q6FG86 Q5TBG9
Accessions	EAW87578 EAW87579 EAW87580 EAW87581 Q9HC98 AB026289 BAA85045 AF087909 AAG13417 AJ420460 AK294614 BAH11825 AK313071 BAG35899 BC000101 AAH00101 BC004174 AAH04174 BC004209 AAH04209 BC012761 AAH12761 BM083872 BP219389 BP265230 BP279761 CF994196 CR457091 CAG33372 CR542222 CAG47018 DB350175 XM_005251664 XP_005251721 XM_006716936 XP_006716999 XM_011518155 XP_011516457 NM_001145001 NP_001138473 NM_001166167 NP_001159639 NM_001166168 NP_001159640 NM_001166169 NP_001159641 NM_001166170 NP_001159642 NM_001166171 NP_001159643 NM_014397 NP_055212
Function	Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. {ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20407017, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361}.
Subcellular Location	Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.
Tissue Specificity	Ubiquitous, with highest expression in heart and skeletal muscle. Up-regulated in a variety of malignant cancers, such as breast, colon, lung, and gastric cancers. {ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:20407017}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Nek6 (D-7) - sc-374491 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Nek6 (A-6) - sc-393837 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Nek6 (C-20) - sc-50751 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Nek6 (G-20) - sc-50752 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Nek6 (H-50) - sc-134833 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Nek6 (N-15) - sc-50754 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-NEK6 antibody [2H7] - ab117986 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2H7

Anti-NEK6 antibody [EPR5282] - ab109177 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5282

Anti-NEK6 antibody [EPR5283] - ab133494 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5283

Anti-NEK6 Antibody (aa38-87) - LS-C81291 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (Internal, clone EPR5282) - LS-C138489 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5282

Anti-NEK6 Antibody (aa251-280, AP) - LS-C208975 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (Internal, clone EPR5283) - LS-C138546 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5283

Anti-NEK6 Antibody (aa251-280, APC) - LS-C208976 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (aa251-280, FITC) - LS-C208978 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (aa251-280, Biotin) - LS-C208977 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (aa251-280, Azide-free, HRP) - LS-C208979 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (aa251-280, PE) - LS-C208982 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (aa250-280) - LS-C323290 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (aa251-280) - LS-C164498 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (clone 8G5) - LS-C114610 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 8G5

Anti-NEK6 Antibody (clone 2H7) - LS-C114648 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2H7

Anti-NEK6 Antibody (clone 5D7) - LS-C114642 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5D7

Anti-NEK6 Antibody (C-Terminus) IHC-plus™ - LS-A7305 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NEK6 Antibody (N-Terminus) IHC-plus™ - LS-A7304 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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