| Gene Symbol | CD4 |
|---|---|
| Entrez Gene | 920 |
| Alt Symbol | CD4mut |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD4 molecule |
| Other Description | CD4 antigen (p55)|CD4 receptor|T-cell surface antigen T4/Leu-3|T-cell surface glycoprotein CD4 |
| Swissprots | P01730 Q9UDE5 Q5U066 D3DUS5 B2R737 Q4ZGK2 |
| Accessions | AAA16069 AAB51309 AAY22175 CAA60883 EAW88738 EAW88739 P01730 AK300052 BAG61861 AK303968 BAG64892 AK308344 AK310652 AK310677 AK310687 AK310750 AK311495 AK312828 BAG35684 AK315898 BAF98789 AK316461 BAH14832 AK316462 BAH14833 BC025782 AAH25782 BT019791 AAV38594 BT019811 AAV38614 BX378810 CA305950 DA384217 DA463597 DA619688 DA639898 DB123455 DQ892052 ABM82978 DQ895246 ABM86172 M12807 AAA35572 S79267 AAB35273 U40625 AAB02789 XM_011521039 XP_011519341 NM_000616 NP_000607 NM_001195014 NP_001181943 NM_001195015 NP_001181944 NM_001195016 NP_001181945 NM_001195017 NP_001181946 NR_036545 |
| Function | Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12517957}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957}. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
| Top Pathways | Hematopoietic cell lineage, T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Antigen processing and presentation |
Human CD4 ELISA Kit (Sandwich ELISA) - LS-F6263 from LifeSpan Bioscience
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Mouse CD4 ELISA Kit (Sandwich ELISA) - LS-F9545 from LifeSpan Bioscience
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Human CD4 ELISA Kit (Sandwich ELISA) - LS-F11086 from LifeSpan Bioscience
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Rat CD4 ELISA Kit (Sandwich ELISA) - LS-F11087 from LifeSpan Bioscience
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Mouse CD4+ T Cell Enrichment Column, Small, Pack of 4 - MCD4C-1000 from R&D Systems
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MagCellect Mouse CD4+ T Cell Isolation Kit - MAGM202 from R&D Systems
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MagCellect Mouse Naive CD4+ T Cell Isolation Kit - MAGM205 from R&D Systems
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MagCellect Rat CD4+ T Cell Isolation Kit - MAGR302 from R&D Systems |
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MagCellect Mouse Memory CD4+ T Cell Isolation Kit - MAGM206 from R&D Systems
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Human CD4+ T Cell Enrichment Column, Small, Pack of 4 - HCD4C-1000 from R&D Systems
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MagCellect Human Memory CD4+ T Cell Isolation Kit - MAGH116 from R&D Systems
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Mouse CD4+ T Cell Enrichment Column, Mini, Pack of 4 - MCD43 from R&D Systems
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Rat CD4+ T Cell Enrichment Column, Small, Pack of 4 - RCD4C-1000 from R&D Systems
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MagCellect Human CD4+ T Cell Isolation Kit - MAGH102 from R&D Systems
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MagCellect Human Naive CD4+ T Cell Isolation Kit - MAGH115 from R&D Systems
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Human CD4+ T Cell Enrichment Column, Mini, Pack of 4 - HCD43 from R&D Systems
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Human CD4 ELISA Kit - abx151002 from Abbexa
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Cluster of Differentiation 4, CD4, Human, ELISA Kit - E-EL-H0752 from ARP American Research Products
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Cluster of differentiation 4, CD4, Human, ELISA Kit - CSB-E08956h from ARP American Research Products
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T-cell surface glycoprotein CD4, CD4, Human, ELISA Kit - E1014h from ARP American Research Products
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Cluster Of Differentiation 4, CD4, Mouse, ELISA Kit - E-EL-M0294 from ARP American Research Products
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Cluster of Differentiation 4, CD4, Rabbit, ELISA Kit - E-EL-RB0179 from ARP American Research Products
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Cluster of Differentiation 4, CD4, Chicken, ELISA Kit - E-EL-Ch1611 from ARP American Research Products
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Cluster of Differentiation 4, CD4, Porcine, ELISA Kit - E-EL-P1634 from ARP American Research Products
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Cluster of Differentiation 4, CD4, Sheep, ELISA Kit - E-EL-S0416 from ARP American Research Products
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