| Gene Symbol | CD4 |
|---|---|
| Entrez Gene | 920 |
| Alt Symbol | CD4mut |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD4 molecule |
| Other Description | CD4 antigen (p55)|CD4 receptor|T-cell surface antigen T4/Leu-3|T-cell surface glycoprotein CD4 |
| Swissprots | P01730 Q9UDE5 Q5U066 D3DUS5 B2R737 Q4ZGK2 |
| Accessions | AAA16069 AAB51309 AAY22175 CAA60883 EAW88738 EAW88739 P01730 AK300052 BAG61861 AK303968 BAG64892 AK308344 AK310652 AK310677 AK310687 AK310750 AK311495 AK312828 BAG35684 AK315898 BAF98789 AK316461 BAH14832 AK316462 BAH14833 BC025782 AAH25782 BT019791 AAV38594 BT019811 AAV38614 BX378810 CA305950 DA384217 DA463597 DA619688 DA639898 DB123455 DQ892052 ABM82978 DQ895246 ABM86172 M12807 AAA35572 S79267 AAB35273 U40625 AAB02789 XM_011521039 XP_011519341 NM_000616 NP_000607 NM_001195014 NP_001181943 NM_001195015 NP_001181944 NM_001195016 NP_001181945 NM_001195017 NP_001181946 NR_036545 |
| Function | Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12517957}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957}. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
| Top Pathways | Hematopoietic cell lineage, T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Antigen processing and presentation |