| Gene Symbol | VTI1A |
|---|---|
| Entrez Gene | 143187 |
| Alt Symbol | MMDS3, MVti1, VTI1RP2, Vti1-rp2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | vesicle transport through interaction with t-SNAREs 1A |
| Other Description | SNARE Vti1a-beta protein|vesicle transport through interaction with t-SNAREs homolog 1A|vesicle transport v-SNARE protein Vti1-like 2 |
| Swissprots | Q96AJ9 B4E137 Q5W0D7 A2A307 |
| Accessions | EAW49524 EAW49525 Q96AJ9 AI610960 AI797732 AK095476 AK303646 BAG64649 BC017052 AAH17052 BC064614 BC067241 BI909044 DA324398 DA472521 HG503273 JF432603 ADZ15820 XM_005269543 XP_005269600 XM_005269544 XP_005269601 XM_005269545 XP_005269602 XM_005269546 XP_005269603 XM_005269547 XP_005269604 XM_005269548 XP_005269605 XM_006717636 XP_006717699 XM_006717637 XP_006717700 XM_011539328 XP_011537630 XM_011539329 XP_011537631 XM_011539330 XP_011537632 XM_011539331 XP_011537633 XM_011539332 XP_011537634 XM_011539333 XP_011537635 NM_145206 NP_660207 |
| Function | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}. |
| Subcellular Location | Cytoplasmic vesicle {ECO:0000269|PubMed:19138172}. Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. |
| Top Pathways | SNARE interactions in vesicular transport |
v-SNARE Vti1a CRISPR/Cas9 KO Plasmid (h) - sc-406891 from Santa Cruz Biotechnology
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v-SNARE Vti1a HDR Plasmid (h) - sc-406891-HDR from Santa Cruz Biotechnology
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v-SNARE Vti1a Double Nickase Plasmid (h) - sc-406891-NIC from Santa Cruz Biotechnology
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v-SNARE Vti1a Double Nickase Plasmid (h2) - sc-406891-NIC-2 from Santa Cruz Biotechnology
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v-SNARE Vti1a CRISPR Activation Plasmid (h) - sc-406891-ACT from Santa Cruz Biotechnology
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v-SNARE Vti1a CRISPR Activation Plasmid (h2) - sc-406891-ACT-2 from Santa Cruz Biotechnology
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v-SNARE Vti1a Lentiviral Activation Particles (h) - sc-406891-LAC from Santa Cruz Biotechnology
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v-SNARE Vti1a Lentiviral Activation Particles (h2) - sc-406891-LAC-2 from Santa Cruz Biotechnology
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v-SNARE Vti1a siRNA (h) - sc-90681 from Santa Cruz Biotechnology
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v-SNARE Vti1a shRNA Plasmid (h) - sc-90681-SH from Santa Cruz Biotechnology
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v-SNARE Vti1a shRNA (h) Lentiviral Particles - sc-90681-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU034461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22753 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22753 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR14046 from Sigma-Aldrich
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VTI1A siRNA (Human) - CRJ5364 from Cohesion Biosciences
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VTI1A - MBS8209675 from MyBioSource
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shRNA set against Human VTI1A (NM_145206.2) - SHH445356 from Creative biogene
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shRNA set against Human VTI1A(NM_145206.2) - SHR190334 from Creative biogene
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Human VTI1A siRNA - orb275865 from Biorbyt
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VTI1A shRNA Plasmid (Human) - CHJ5364 from Cohesion Biosciences
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VTI1A miRNA 3'UTR clone - MiUTR1H-11176 from Creative biogene
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