| Gene Symbol |
PTPN23
|
| Entrez Gene |
25930
|
| Alt Symbol |
HD-PTP, HDPTP, PTP-TD14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, non-receptor type 23
|
| Other Description |
his domain-containing protein tyrosine phosphatase|protein tyrosine phosphatase TD14|tyrosine-protein phosphatase non-receptor type 23
|
| Swissprots |
Q8N6Z5 Q9P257 Q9BSR5 Q9UMZ4 Q9H3S7 Q9UG03 A8K0D7 Q7KZF8
|
| Accessions |
EAW64822 EAW64823 EAW64824 Q9H3S7 AB025194 BAB19280 AB040904 BAA95995 AF169350 AAD50276 AF290614 AAK28025 AK055157 AK289502 BAF82191 AK295877 BAG58674 AK295888 BAG58683 AK299906 BAG61747 AL110210 CAB53676 BC004881 AAH04881 BC020380 BC027711 AAH27711 BC089042 AAH89042 BT009758 AAP88760 BU173747 DA093189 XM_005265031 XP_005265088 NM_001304482 NP_001291411 NM_015466 NP_056281
|
| Function |
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.
|