PTPN23

Gene Symbol PTPN23
Entrez Gene 25930
Alt Symbol HD-PTP, HDPTP, PTP-TD14
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 23
Other Description his domain-containing protein tyrosine phosphatase|protein tyrosine phosphatase TD14|tyrosine-protein phosphatase non-receptor type 23
Swissprots Q8N6Z5 Q9P257 Q9BSR5 Q9UMZ4 Q9H3S7 Q9UG03 A8K0D7 Q7KZF8
Accessions EAW64822 EAW64823 EAW64824 Q9H3S7 AB025194 BAB19280 AB040904 BAA95995 AF169350 AAD50276 AF290614 AAK28025 AK055157 AK289502 BAF82191 AK295877 BAG58674 AK295888 BAG58683 AK299906 BAG61747 AL110210 CAB53676 BC004881 AAH04881 BC020380 BC027711 AAH27711 BC089042 AAH89042 BT009758 AAP88760 BU173747 DA093189 XM_005265031 XP_005265088 NM_001304482 NP_001291411 NM_015466 NP_056281
Function Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}.
Subcellular Location Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.

HD-PTP (F-4) - sc-398711 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HD-PTP (F-4): sc-398711. Western blot analysis of HD-PTP expression in HeLa (A), A-375 (C) and Hep G2 (D) whole cell lysates, HeLa nuclear extract (B) and human liver tissue extract (E).

HD-PTP (C-20) - sc-55205 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HD-PTP (C-20): sc-55205. Western blot analysis of HD-PTP expression in HeLa (A) and A-375 (B) whole cell lysates.

Anti-HDPTP antibody - ab12553 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab12553 stained MALME-3M cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab12553 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PTPN23 / HDPTP Antibody (aa1180-1209, AP) - LS-C267564 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN23 / HDPTP Antibody (aa1180-1209, APC) - LS-C267565 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN23 / HDPTP Antibody (aa1180-1209, Biotin) - LS-C267566 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN23 / HDPTP Antibody (aa1180-1209, FITC) - LS-C267567 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN23 / HDPTP Antibody (aa1180-1209, Azide-free, HRP) - LS-C267568 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN23 / HDPTP Antibody (aa1180-1209, PE) - LS-C267569 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN23 / HDPTP Antibody (aa1180-1209) - LS-C324419 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN23 / HDPTP Antibody (aa1180-1209) - LS-C158769 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PTPN23 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The PTPN23 antibody detected the PTPN23 protein (arrow).

PTPN23 Antibody - NBP2-36549 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTPN23 Antibody [NBP2-36549] - Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-HD-PTP antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

PTPN23 Antibody - H00025930-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: PTPN23 Antibody [H00025930-B01P] - Analysis of PTPN23 expression in transfected 293T cell line by PTPN23 polyclonal antibody. Lane 1: PTPN23 transfected lysate(63.47 KDa). Lane 2: Non-transfected lysate.

PTPN23 Antibody - NBP1-84158 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: PTPN23 Antibody [NBP1-84158] - Staining of human cell line A-431 shows localization to nucleoplasm & nuclear bodies.

HDPTP Polyclonal Antibody - bs-15434R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded rat brain; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with HDPTP Polyclonal Antibody (bs-15434R) at 1:400 overnight at 4°C, followed by a SP kit and DAB staining.

PTPN23-Antibody-C-term - AP17418b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PTPN23 Antibody (C-term) (Cat. #AP17418b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PTPN23 antibody detected the PTPN23 protein (arrow).

PTPN23 Antibody - C-terminal region (OAAB12849) - OAAB12849 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PTPN23 Polyclonal Antibody - A4595 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cells, using PTPN23 antibody.

PTPN23 antibody - 70R-19643 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

HDPTP Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-15434R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HDPTP Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-15434R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HDPTP Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-15434R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HDPTP Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-15434R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HDPTP Polyclonal Antibody, Cy3 Conjugated - bs-15434R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HDPTP Polyclonal Antibody, Cy5 Conjugated - bs-15434R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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