| Gene Symbol |
Fbxo32
|
| Entrez Gene |
171043
|
| Alt Symbol |
Atrogin1, MAFbx
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 32
|
| Other Description |
F-box only protein 32|atrogin-1|atrophy gene 1|muscle atrophy F-box protein
|
| Swissprots |
Q91Z62
|
| Accessions |
EDM16222 Q91Z62 AY059628 AAL16406 NM_133521 NP_598205
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between Cytoplasm and the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Specifically expressed in cardiac and skeletal muscle.
|