| Gene Symbol |
ECM1
|
| Entrez Gene |
1893
|
| Alt Symbol |
URBWD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
extracellular matrix protein 1
|
| Other Description |
secretory component p85
|
| Swissprots |
A8K8S0 Q8IZ60 Q5T5G5 Q5T5G6 Q5T5G4 Q16610 O43266 B4DW49 B4DY60
|
| Accessions |
AAB05934 ACV13189 EAW53544 EAW53545 EAW53546 EAW53547 Q16610 AK097046 BAG53412 AK097205 AK292435 BAF85124 AK301369 BAG62911 AK302279 BAG63622 AK316390 BAH14761 BC023505 AAH23505 CA413352 DA963826 DQ010946 AAY57437 DQ112074 ABA29445 DQ893011 ABM83937 DQ896257 ABM87256 U65932 AAB05933 U68186 AAB88081 U68187 AAB88082 NM_001202858 NP_001189787 NM_004425 NP_004416 NM_022664 NP_073155
|
| Function |
Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. {ECO:0000269|PubMed:11165938, ECO:0000269|PubMed:11292659, ECO:0000269|PubMed:16512877}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix.
|
| Tissue Specificity |
Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis. {ECO:0000269|PubMed:11292659, ECO:0000269|PubMed:12604605}.
|