Gene Symbol | NCOA5 |
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Entrez Gene | 57727 |
Alt Symbol | CIA, bA465L10.6 |
Species | Human |
Gene Type | protein-coding |
Description | nuclear receptor coactivator 5 |
Other Description | NCoA-5|coactivator independent of AF-2 |
Swissprots | Q9HCD5 Q9H4Y9 E1P5R0 Q6HA99 Q9H2T2 B2RTV9 Q9H1F2 |
Accessions | CAJ42777 EAW75764 EAW75765 EAW75766 EAW75767 EAW75768 EAW75769 EAW75770 Q9HCD5 AB046857 BAB13463 AF230533 AAG36793 AF470686 AAO33457 BC056872 BC140836 AAI40837 BC151133 AAI51134 CN369226 XM_005260474 XP_005260531 XM_011528951 XP_011527253 NM_020967 NP_066018 |
Function | Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Widely expressed. |
NCoA-5 CRISPR/Cas9 KO Plasmid (h) - sc-406268 from Santa Cruz Biotechnology
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NCoA-5 HDR Plasmid (h) - sc-406268-HDR from Santa Cruz Biotechnology
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NCoA-5 Double Nickase Plasmid (h) - sc-406268-NIC from Santa Cruz Biotechnology
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NCoA-5 Double Nickase Plasmid (h2) - sc-406268-NIC-2 from Santa Cruz Biotechnology
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NCoA-5 CRISPR Activation Plasmid (h) - sc-406268-ACT from Santa Cruz Biotechnology
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NCoA-5 CRISPR Activation Plasmid (h2) - sc-406268-ACT-2 from Santa Cruz Biotechnology
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NCoA-5 Lentiviral Activation Particles (h) - sc-406268-LAC from Santa Cruz Biotechnology
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NCoA-5 Lentiviral Activation Particles (h2) - sc-406268-LAC-2 from Santa Cruz Biotechnology
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NCoA-5 siRNA (h) - sc-75885 from Santa Cruz Biotechnology
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NCoA-5 shRNA Plasmid (h) - sc-75885-SH from Santa Cruz Biotechnology
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NCoA-5 shRNA (h) Lentiviral Particles - sc-75885-V from Santa Cruz Biotechnology
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NCOA5 RNAi - H00057727-R01 from Novus Biologicals
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MISSION® esiRNA - EHU074601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15031 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13103 from Sigma-Aldrich
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NCOA5 siRNA (Human) - CRJ1664 from Cohesion Biosciences
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shRNA set against Human NCOA5 (NM_020967.2) - SHH350120 from Creative biogene
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shRNA set against Human NCOA5(NM_020967.2) - SHR001154 from Creative biogene
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Human NCOA5 siRNA - orb272165 from Biorbyt
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NCOA5 shRNA Plasmid (Human) - CHJ1664 from Cohesion Biosciences
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NCOA5 miRNA 3'UTR clone - MiUTR3H-15577 from Creative biogene
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