| Gene Symbol | Sgpl1 |
|---|---|
| Entrez Gene | 20397 |
| Alt Symbol | AI428538, D10Xrf456, S1PL, Spl |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | sphingosine phosphate lyase 1 |
| Other Description | SP-lyase 1|SPL 1|mSPL|sphingosine-1-phosphate aldolase|sphingosine-1-phosphate lyase 1 |
| Swissprots | Q8R0X7 O54955 Q8C942 |
| Accessions | EDL32155 EDL32156 EDL32157 EDL32158 EDL32159 Q8R0X7 AF036894 AAC03768 AI428538 AK036747 BAC29562 AK037789 BAC29872 AK043024 BAC31437 AK049342 BAC33695 AK075851 AK150053 BAE29269 AK173137 BAD32415 AK180858 AK190149 AK191088 AK192177 AK192450 AK193418 AK193544 AK195290 AK196230 AK196336 AK197017 AK197939 AK199228 AK202302 AK204326 AK208741 AK209049 AK209156 AK209672 AK210156 AK218018 BC026135 AAH26135 BY061956 BY075752 CT010214 CAJ18422 XM_006513402 XP_006513465 XM_006513403 XP_006513466 NM_009163 NP_033189 |
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:9464245}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. |
| Tissue Specificity | Highest levels are found in liver, followed by kidney, lung, heart and brain. {ECO:0000269|PubMed:9464245}. |
| Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |