| Gene Symbol |
Irak2
|
| Entrez Gene |
108960
|
| Alt Symbol |
6330415L08Rik, AI649099, IRAK-2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
interleukin-1 receptor-associated kinase 2
|
| Other Description |
interleukin-1 receptor-associated kinase 2c|interleukin-1 receptor-associated kinase-like 2|mu-IRAK-2
|
| Swissprots |
Q6YBS1 Q8CFA1 Q6YBS0 Q3UFX2 Q6YBR9 Q3U7F5 Q6YBR8 Q8CEA0 Q8CC82 Q3U3K2 Q8C5M0 Q5U404
|
| Accessions |
EDK99493 Q8CFA1 AJ440756 CAD29447 AK028733 BAC26088 AK033707 BAC28438 AK078062 BAC37114 AK148248 BAE28437 AK150056 BAE29271 AK151428 BAE30392 AK152682 BAE31414 AK154715 BAE32783 AY162378 AAO24761 AY162379 AAO24762 AY162380 AAO24763 AY162381 AAO24764 BC085324 AAH85324 BY110939 CJ212338 XM_006505325 XP_006505388 NM_001113553 NP_001107025 NM_172161 NP_751893
|
| Function |
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed, with a higher expression observed in brain, spleen and liver. Isoform 1 and isoform 2 are considered agonist and isoform 3 and isoform 4 are considered antagonist.
|
| Top Pathways |
Apoptosis, Neurotrophin signaling pathway, Tuberculosis
|