| Gene Symbol |
NPFFR2
|
| Entrez Gene |
10886
|
| Alt Symbol |
GPR74, HLWAR77, NPFF2, NPGPR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuropeptide FF receptor 2
|
| Other Description |
G protein-coupled receptor 74|G-protein coupled receptor 74|G-protein coupled receptor HLWAR77|neuropeptide FF 2|neuropeptide G-protein coupled receptor
|
| Swissprots |
Q9NR49 Q96RV1 Q9Y5X5
|
| Accessions |
EAX05647 EAX05648 EAX05649 EAX05650 Q9Y5X5 AF119815 AAD22047 AF236083 AAK58513 AF257210 AAF87078 AF268899 AAG41398 AF330053 AAK94197 AJ311393 CAC85427 AK290937 BAF83626 AK308069 BC101636 AAI01637 BC113713 AAI13714 CN285250 XM_011531554 XP_011529856 NM_001144756 NP_001138228 NM_004885 NP_004876 NM_053036 NP_444264
|
| Function |
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas. {ECO:0000269|PubMed:10079187}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|