dis3

Gene Symbol dis3
Entrez Gene 2540398
Alt Symbol rrp44
Species S. pombe
Gene Type protein-coding
Description 3'-5' exoribonuclease subunit Dis3 (predicted)
Other Description -
Swissprots P37202
Accessions CAA21102 P37202 NM_001022575 NP_596653
Function Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. DIS3 has both
Subcellular Location Cytoplasm. Nucleus. Note=Abundant in the nucleus.
Top Pathways RNA degradation

Anti-Dis3 antibody - ab64289 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunfluorescent analysis of S. pombe cells labeling Dis3 with ab64289 (right panel). DAPI stain for chromosomal DNA (left panel).

Anti-S. pombe DIS3 Polyclonal antibody - DPABH-29313 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Dis3 (S. pombe) antibody - GTX64107 from GeneTex

Prices $319.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Anti-Dis3 (S. pombe) antibody used in Western blot. GTX64107
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