GANAB
| Gene Symbol | GANAB |
|---|---|
| Entrez Gene | 23193 |
| Alt Symbol | G2AN, GLUII |
| Species | Human |
| Gene Type | protein-coding |
| Description | glucosidase, alpha; neutral AB |
| Other Description | HEL-S-164nA|alpha glucosidase II alpha subunit|alpha-glucosidase 2|epididymis secretory sperm binding protein Li 164nA|glucosidase II subunit alpha|neutral alpha-glucosidase AB |
| Swissprots | A6NC20 Q9P0X0 Q8WTS9 Q14697 |
| Accessions | AAM83349 EAW74045 EAW74046 EAW74047 EAW74048 EAW74049 EAW74050 Q14697 AA618561 AF144074 AAF66685 AJ000332 CAA04006 AK026548 AK026567 AK026997 AK295806 BAG58624 AK299819 BAG61688 AK302752 BAG63965 AK314370 BC005405 AAH05405 BC017433 AAH17433 BC017435 AAH17435 BC034439 BC065266 AAH65266 BG720650 D42041 BAA07642 DC400833 EU794613 ACJ13667 NM_014610 NM_001278192 NP_001265121 NM_001278193 NP_001265122 NM_001278194 NP_001265123 NM_198334 NP_938148 NM_198335 NP_938149 |
| Function | Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. {ECO:0000269|PubMed:10929008}. |
| Subcellular Location | Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Melanosome {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Specificity | Detected in placenta. {ECO:0000269|PubMed:3881423}. |
| Top Pathways | N-Glycan biosynthesis, Protein processing in endoplasmic reticulum |
Glucosidase IIα CRISPR/Cas9 KO Plasmid (h) - sc-407683 from Santa Cruz Biotechnology
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Glucosidase IIα HDR Plasmid (h) - sc-407683-HDR from Santa Cruz Biotechnology
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Glucosidase IIα Double Nickase Plasmid (h) - sc-407683-NIC from Santa Cruz Biotechnology
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Glucosidase IIα Double Nickase Plasmid (h2) - sc-407683-NIC-2 from Santa Cruz Biotechnology
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Glucosidase IIα CRISPR Activation Plasmid (h) - sc-407683-ACT from Santa Cruz Biotechnology
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Glucosidase IIα CRISPR Activation Plasmid (h2) - sc-407683-ACT-2 from Santa Cruz Biotechnology
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Glucosidase IIα Lentiviral Activation Particles (h) - sc-407683-LAC from Santa Cruz Biotechnology
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Glucosidase IIα Lentiviral Activation Particles (h2) - sc-407683-LAC-2 from Santa Cruz Biotechnology
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Glucosidase IIα siRNA (h) - sc-41517 from Santa Cruz Biotechnology
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Glucosidase IIα shRNA Plasmid (h) - sc-41517-SH from Santa Cruz Biotechnology
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Glucosidase IIα shRNA (h) Lentiviral Particles - sc-41517-V from Santa Cruz Biotechnology
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alpha Glucosidase 2 RNAi - H00023193-R02 from Novus Biologicals
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MISSION® esiRNA - EHU083651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9126 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9126 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07499 from Sigma-Aldrich
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GANAB siRNA (Human) - CRH8073 from Cohesion Biosciences
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alpha Glucosidase 2 RNAi - H00023193-R01 from Novus Biologicals
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GANAB - MBS8223881 from MyBioSource
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shRNA set against Human GANAB (NM_198334.1) - SHH299257 from Creative biogene
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shRNA set against Human GANAB(NM_198335.2) - SHH077087 from Creative biogene
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shRNA set against Human GANAB(NM_198334.1) - SHH077093 from Creative biogene
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shRNA set against Human GANAB(NM_198335.2) - SHH077129 from Creative biogene
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Human GANAB siRNA - orb268575 from Biorbyt
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GANAB shRNA Plasmid (Human) - CHH8073 from Cohesion Biosciences
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