| Gene Symbol |
DPP4
|
| Entrez Gene |
281122
|
| Alt Symbol |
CD26, DPPIV
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
dipeptidyl-peptidase 4
|
| Other Description |
ACT3|ADCP-I|DPP IV|T-cell activation antigen CD26|WC10|activation molecule 3|adenosine deaminase complexing protein|dipeptidyl peptidase 4|dipeptidyl peptidase IV|dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)|dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
|
| Swissprots |
P81425 Q3ZCC2 Q8WMG8
|
| Accessions |
AAG49484 AAG49485 AAG49486 AAG49487 DAA32665 P81425 AF461806 AAL67836 AY056834 AAL23628 BC102523 AAI02524 NM_174039 NP_776464
|
| Function |
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth fact
|
| Subcellular Location |
Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid. {ECO:0000250}.
|
| Tissue Specificity |
Intestinal epithelium, dendritic cells and several immune system tissues.
|
| Top Pathways |
Protein digestion and absorption
|