Gene Symbol | DPP4 |
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Entrez Gene | 281122 |
Alt Symbol | CD26, DPPIV |
Species | Bovine |
Gene Type | protein-coding |
Description | dipeptidyl-peptidase 4 |
Other Description | ACT3|ADCP-I|DPP IV|T-cell activation antigen CD26|WC10|activation molecule 3|adenosine deaminase complexing protein|dipeptidyl peptidase 4|dipeptidyl peptidase IV|dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)|dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) |
Swissprots | P81425 Q3ZCC2 Q8WMG8 |
Accessions | AAG49484 AAG49485 AAG49486 AAG49487 DAA32665 P81425 AF461806 AAL67836 AY056834 AAL23628 BC102523 AAI02524 NM_174039 NP_776464 |
Function | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth fact |
Subcellular Location | Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid. {ECO:0000250}. |
Tissue Specificity | Intestinal epithelium, dendritic cells and several immune system tissues. |
Top Pathways | Protein digestion and absorption |
Anti-CD26 antibody - ab62816 from Abcam
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Anti-CD26 antibody - ab61825 from Abcam
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Anti-CD26 antibody - ab189060 from Abcam
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Anti-CD26 antibody - ab140780 from Abcam
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Anti-CD26 antibody [CC69] - ab23237 from Abcam
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DPPIV/CD26 Antibody (CC69) - NB100-65891 from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [PerCP] - NB100-65891PCP from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [DyLight 350] - NB100-65891UV from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [DyLight 488] - NB100-65891G from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [DyLight 755] - NB100-65891IR from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [Alexa Fluor (R) 700] - NB100-65891AF700 from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [Alexa Fluor (R) 647] - NB100-65891AF647 from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [Alexa Fluor (R) 488] - NB100-65891AF488 from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [Alexa Fluor (R) 405] - NB100-65891AF405 from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [DyLight 405] - NB100-65891V from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [PE] - NB100-65891PE from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [7C] - NB100-65891V2 from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [Allophycocyanin] - NB100-65891APC from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [DyLight 680] - NB100-65891FR from Novus Biologicals
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DPPIV/CD26 Antibody (CC69) [DyLight 405LS] - NB100-65891V3 from Novus Biologicals
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DPP4 Antibody (OASA00277) - OASA00277 from Aviva Systems Biology
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DPP4 Antibody (OASA00278) - OASA00278 from Aviva Systems Biology
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CD26 antibody [CC69] - GTX42188 from GeneTex
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CD26 antibody [CC69] - GTX42189 from GeneTex
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Anti -CD26 (ADABP, ADCP2, Adenosine Deaminase Complexing Protein 2, Dipeptidyl PeptidaseIV, Dipeptidylpeptidase 4, DPP4, DPPIV, Intestinal Dipeptidyl Peptidase, T cell ActivationAntigen CD26, TP103) - C2277-06P from USBiological Life Science
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