| Gene Symbol |
ITLN1
|
| Entrez Gene |
55600
|
| Alt Symbol |
HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
intelectin 1 (galactofuranose binding)
|
| Other Description |
ITLN-1|endothelial lectin HL-1|galactofuranose-binding lectin|intelectin-1|intestinal lactoferrin receptor
|
| Swissprots |
Q8WWA0 Q9NP67 Q6YDJ3 Q5VYI4 Q5IWS4
|
| Accessions |
EAW52688 EAW52689 EAW52690 Q8WWA0 AB036706 BAA96094 AF271386 AAM20741 AK000029 BAA90893 AK222533 BAD96253 AY065972 AAL58073 AY157361 AAO17800 AY157362 AAO17801 AY358359 AAQ88725 AY549722 AAS49907 AY619691 AAU88047 AY619692 AAU88048 BC020664 AAH20664 CR457224 CAG33505 EU832610 ACE87701 EU832681 ACE87013 HQ447701 ADQ32186 NM_017625 NP_060095
|
| Function |
Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism. {ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:16531507}.
|
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus. {ECO:0000269|PubMed:11181563, ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:11747454, ECO:0000269|PubMed:16531507}.
|