Gene Symbol | DCD |
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Entrez Gene | 117159 |
Alt Symbol | AIDD, DCD-1, DSEP, HCAP, PIF |
Species | Human |
Gene Type | protein-coding |
Description | dermcidin |
Other Description | diffusible survival/evasion peptide|preproteolysin|proteolysis inducing factor|survival promoting peptide |
Swissprots | A5JHP3 P58461 A5JHP2 P81605 Q53YJ2 |
Accessions | AAK94785 AAL25801 EAW96794 P81605 AF144011 AAL18349 AY590150 AAS99907 BC062682 AAH62682 BC069108 AAH69108 BP313072 EF503687 ABQ53649 EF503688 ABQ53650 EF503689 ABQ53651 HQ447604 ADQ32090 NM_001300854 NP_001287783 NM_053283 NP_444513 |
Function | DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. |
Subcellular Location | Secreted. |
Tissue Specificity | Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml. |
Dermcidin CRISPR/Cas9 KO Plasmid (h) - sc-401346 from Santa Cruz Biotechnology
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Dermcidin HDR Plasmid (h) - sc-401346-HDR from Santa Cruz Biotechnology
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Dermcidin Double Nickase Plasmid (h) - sc-401346-NIC from Santa Cruz Biotechnology
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Dermcidin Double Nickase Plasmid (h2) - sc-401346-NIC-2 from Santa Cruz Biotechnology
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Dermcidin CRISPR Activation Plasmid (h) - sc-401346-ACT from Santa Cruz Biotechnology
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Dermcidin CRISPR Activation Plasmid (h2) - sc-401346-ACT-2 from Santa Cruz Biotechnology
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Dermcidin Lentiviral Activation Particles (h) - sc-401346-LAC from Santa Cruz Biotechnology
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Dermcidin Lentiviral Activation Particles (h2) - sc-401346-LAC-2 from Santa Cruz Biotechnology
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Dermcidin siRNA (h) - sc-105288 from Santa Cruz Biotechnology
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Dermcidin shRNA Plasmid (h) - sc-105288-SH from Santa Cruz Biotechnology
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Dermcidin shRNA (h) Lentiviral Particles - sc-105288-V from Santa Cruz Biotechnology
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Dermcidin RNAi - H00117159-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN6979 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6979 from Sigma-Aldrich
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DCD siRNA (Human) - CRJ4555 from Cohesion Biosciences
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DCD - MBS8212128 from MyBioSource
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Dermcidin CRISPR/Cas9 KO Plasmid (h2) - sc-401346-KO-2 from Santa Cruz Biotechnology
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Dermcidin HDR Plasmid (h2) - sc-401346-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human DCD (NM_053283.2) - SHH275073 from Creative biogene
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DCD shRNA Plasmid (Human) - CHJ4555 from Cohesion Biosciences
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DCD miRNA 3'UTR clone - MiUTR1H-02685 from Creative biogene
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