| Gene Symbol |
EYA3
|
| Entrez Gene |
2140
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EYA transcriptional coactivator and phosphatase 3
|
| Other Description |
eyes absent 3|eyes absent homolog 3
|
| Swissprots |
B4DIR7 A8K190 Q99813 Q8IVX7 O95463 Q99504 B4DNZ7
|
| Accessions |
CAA71311 EAX07713 EAX07714 Q99504 AJ007991 CAA07814 AK289805 BAF82494 AK295745 BAG58579 AK298129 BAG60409 AK303664 BAG64663 AL603098 BC029500 AAH29500 BC041667 AAH41667 BQ018346 BX648945 CA434977 CR748247 DC416048 DQ426872 DQ576790 EU446857 ABZ92386 U81602 AAB42066 XM_006710449 XP_006710512 XM_011540999 XP_011539301 XM_011541000 XP_011539302 XM_011541001 XP_011539303 XM_011541002 XP_011539304 XM_011541003 XP_011539305 XM_011541004 XP_011539306 XM_011541005 XP_011539307 XM_011541006 XP_011539308 XR_946582 NM_001282560 NP_001269489 NM_001282561 NP_001269490 NM_001282562 NP_001269491 NM_001990 NP_001981 NR_104214 NM_172098
|
| Function |
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:19234442}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively (By similarity). {ECO:0000250}.
|