Gene Symbol |
HAAO
|
Entrez Gene |
23498
|
Alt Symbol |
3-HAO, HAO
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
3-hydroxyanthranilate 3,4-dioxygenase
|
Other Description |
3-HAO|3-hydroxyanthranilate oxygenase|3-hydroxyanthranilic acid dioxygenase|HAD
|
Swissprots |
Q8N6N9 P46952 A6NE56 Q53QZ7 B4DIN2
|
Accessions |
AAY14701 EAX00309 EAX00310 EAX00311 P46952 AK295693 BAG58544 BC029510 AAH29510 BI602406 CB850657 CR457063 CAG33344 DQ891168 ABM82094 DQ894350 ABM85276 DT215851 Z29481 CAA82618 XM_005264230 XP_005264287 XM_011532729 XP_011531031 XM_011532730 XP_011531032 XM_011532731 XP_011531033 NM_012205 NP_036337
|
Function |
Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. {ECO:0000255|HAMAP- Rule:MF_03019, ECO:0000269|PubMed:7514594}.
|
Subcellular Location |
Cytoplasm.
|
Top Pathways |
Tryptophan metabolism
|