Gene Symbol | HAAO |
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Entrez Gene | 23498 |
Alt Symbol | 3-HAO, HAO |
Species | Human |
Gene Type | protein-coding |
Description | 3-hydroxyanthranilate 3,4-dioxygenase |
Other Description | 3-HAO|3-hydroxyanthranilate oxygenase|3-hydroxyanthranilic acid dioxygenase|HAD |
Swissprots | Q8N6N9 P46952 A6NE56 Q53QZ7 B4DIN2 |
Accessions | AAY14701 EAX00309 EAX00310 EAX00311 P46952 AK295693 BAG58544 BC029510 AAH29510 BI602406 CB850657 CR457063 CAG33344 DQ891168 ABM82094 DQ894350 ABM85276 DT215851 Z29481 CAA82618 XM_005264230 XP_005264287 XM_011532729 XP_011531031 XM_011532730 XP_011531032 XM_011532731 XP_011531033 NM_012205 NP_036337 |
Function | Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. {ECO:0000255|HAMAP- Rule:MF_03019, ECO:0000269|PubMed:7514594}. |
Subcellular Location | Cytoplasm. |
Top Pathways | Tryptophan metabolism |
HAAO CRISPR/Cas9 KO Plasmid (h) - sc-411750 from Santa Cruz Biotechnology
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HAAO HDR Plasmid (h) - sc-411750-HDR from Santa Cruz Biotechnology
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HAAO Double Nickase Plasmid (h) - sc-411750-NIC from Santa Cruz Biotechnology
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HAAO Double Nickase Plasmid (h2) - sc-411750-NIC-2 from Santa Cruz Biotechnology
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HAAO CRISPR Activation Plasmid (h) - sc-411750-ACT from Santa Cruz Biotechnology
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HAAO CRISPR Activation Plasmid (h2) - sc-411750-ACT-2 from Santa Cruz Biotechnology
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HAAO Lentiviral Activation Particles (h) - sc-411750-LAC from Santa Cruz Biotechnology
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HAAO Lentiviral Activation Particles (h2) - sc-411750-LAC-2 from Santa Cruz Biotechnology
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HAAO siRNA (h) - sc-94902 from Santa Cruz Biotechnology
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HAAO shRNA Plasmid (h) - sc-94902-SH from Santa Cruz Biotechnology
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HAAO shRNA (h) Lentiviral Particles - sc-94902-V from Santa Cruz Biotechnology
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HAAO RNAi - H00023498-R01 from Novus Biologicals
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MISSION® esiRNA - EHU155631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9852 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9852 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12085 from Sigma-Aldrich
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HAAO siRNA (Human) - CRH8306 from Cohesion Biosciences
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HAAO - MBS8237472 from MyBioSource
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shRNA set against Human HAAO (NM_012205.2) - SHH310077 from Creative biogene
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Human HAAO siRNA - orb268808 from Biorbyt
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HAAO shRNA Plasmid (Human) - CHH8306 from Cohesion Biosciences
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HAAO miRNA 3'UTR clone - MiUTR3H-06885 from Creative biogene
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