ALOX15B

Gene Symbol	ALOX15B
Entrez Gene	247
Alt Symbol	15-LOX-2
Species	Human
Gene Type	protein-coding
Description	arachidonate 15-lipoxygenase, type B
Other Description	15-LOX-B|15S-lipoxygenase|arachidonate 15-lipoxygenase 2|arachidonate 15-lipoxygenase B|arachidonate 15-lipoxygenase type II|arachidonate 15-lipoxygenase, second type|arachidonate omega(6) lipoxygenase|linoleate 13-lipoxygenase 15-LOb
Swissprots	Q8TEV5 Q8TEV3 D3DTR2 Q9UKM4 Q8TEV6 Q8TEV4 Q8IYQ2 O15296
Accessions	AAD37786 CAC34521 EAW90097 EAW90098 EAW90099 EAW90100 EAW90101 EAW90102 O15296 AF468051 AAL76274 AF468052 AAL76275 AF468053 AAL76276 AF468054 AAL76277 AK292779 BAF85468 AK298095 BAG60380 AK300554 BAG62260 BC033294 BC035217 AAH35217 BC063647 AAH63647 BP327830 CA307212 CA405703 DQ891345 ABM82271 EU176579 ABW03380 U78294 AAB61706 NM_001039130 NP_001034219 NM_001039131 NP_001034220 NM_001141 NP_001132
Function	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells. {ECO:0000269|PubMed:10625675, ECO:0000269|PubMed:11839751, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:16112079, ECO:0000269|PubMed:18067895, ECO:0000269|PubMed:22912809, ECO:0000269|PubMed:24497644}.
Subcellular Location	Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus.
Tissue Specificity	Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea. {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:11350124, ECO:0000269|PubMed:9177185}.
Top Pathways	Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Lipoxygenase Inhibitor Screening Assay Kit - ab133087 from Abcam Category Cellular Assay

Human ALOX15B / 15-LOX-2 ELISA Kit (Sandwich ELISA) - LS-F9927 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Human ALOX15B ELISA Kit - abx150619 from Abbexa Category ELISA Kit Sensitivity 0.059 ng/ml Range 0.156 ng/ml - 10 ng/ml

Arachidonate 15-lipoxygenase B (ALOX15B), Human, ELISA Kit - CSB-EL001622HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.03 pg/ml Range 28.12 pg/ml-1800 pg/ml

Arachidonate 15-lipoxygenase B (ALOX15B), Human, ELISA Kit - E01A1401 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Arachidonate 15-lipoxygenase B, ALOX15B, Human, ELISA Kit - E1356h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Arachidonate 15 lipoxygenase B (ALOX15B), ELISA Kit - MBS7215220 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

arachidonate 15-lipoxygenase, type B, ELISA Kit - MBS914061 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 7 pg/ml. Range 28 pg/ml -1800 pg/ml.

ALOX15B, ELISA Kit - MBS2516089 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Arachidonate-15-Lipoxygenase, Type B (ALOX15B), ELISA Kit - MBS2024894 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.059ng/mL. Range 0.156-10ng/mL

ELISA Kit for Arachidonate-15-Lipoxygenase, Type B (ALOX15B) - SEB356Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Arachidonate 15-lipoxygenase B(ALOX15B) ELISA kit - CSB-EL001622HU from Cusabio Category ELISA Kit Sensitivity 7 pg/ml. Range 28 pg/ml-1800 pg/ml

ELISA Kit for Arachidonate-15-Lipoxygenase, Type B (ALOX15B) - SEB356Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat ALOX15B / 15-LOX-2 ELISA Kit (Custom ELISA) - LS-F17003 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse ALOX15B / 15-LOX-2 ELISA Kit (Custom ELISA) - LS-F17002 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human ALOX15B / 15-LOX-2 ELISA Kit (Custom ELISA) - LS-F17004 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human ALOX15B(Arachidonate-15-Lipoxygenase, Type B) ELISA Kit - E-EL-H2424 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human Arachidonate 15-lipoxygenase B ELISA Kit - abx250811 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Human ALOX15B / 15-LOX-2 ELISA Kit (Sandwich ELISA) - LS-F21267 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

Human ALOX15B(Arachidonate-15-Lipoxygenase, Type B) ELISA Kit - E-EL-H2424 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human Arachidonate 15-lipoxygenase B (ALOX15B) ELISA Kit - EKC32784 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7 pg/ml Range 28 pg/ml-1800 pg/ml

Human Arachidonate 15-lipoxygenase B ELISA Kit - EKE53252 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.098 ng/mL Range 0.312-20 ng/mL

ALOX15B - EKH3052 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Human ALOX15B ELISA Kit - E003522 from Biobool Category ELISA Kit Sensitivity 0.1 ng/mL.

ALOX15B ELISA Kit (Human) (OKEH04836) - OKEH04836 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity < 0.15 ng/mL Range 0.312 - 20 ng/mL

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