ALOX15B

Gene Symbol	ALOX15B
Entrez Gene	247
Alt Symbol	15-LOX-2
Species	Human
Gene Type	protein-coding
Description	arachidonate 15-lipoxygenase, type B
Other Description	15-LOX-B|15S-lipoxygenase|arachidonate 15-lipoxygenase 2|arachidonate 15-lipoxygenase B|arachidonate 15-lipoxygenase type II|arachidonate 15-lipoxygenase, second type|arachidonate omega(6) lipoxygenase|linoleate 13-lipoxygenase 15-LOb
Swissprots	Q8TEV5 Q8TEV3 D3DTR2 Q9UKM4 Q8TEV6 Q8TEV4 Q8IYQ2 O15296
Accessions	AAD37786 CAC34521 EAW90097 EAW90098 EAW90099 EAW90100 EAW90101 EAW90102 O15296 AF468051 AAL76274 AF468052 AAL76275 AF468053 AAL76276 AF468054 AAL76277 AK292779 BAF85468 AK298095 BAG60380 AK300554 BAG62260 BC033294 BC035217 AAH35217 BC063647 AAH63647 BP327830 CA307212 CA405703 DQ891345 ABM82271 EU176579 ABW03380 U78294 AAB61706 NM_001039130 NP_001034219 NM_001039131 NP_001034220 NM_001141 NP_001132
Function	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells. {ECO:0000269|PubMed:10625675, ECO:0000269|PubMed:11839751, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:16112079, ECO:0000269|PubMed:18067895, ECO:0000269|PubMed:22912809, ECO:0000269|PubMed:24497644}.
Subcellular Location	Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus.
Tissue Specificity	Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea. {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:11350124, ECO:0000269|PubMed:9177185}.
Top Pathways	Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human 15 Lipoxygenase 2 full length protein - ab132282 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human 15 Lipoxygenase 2 protein fragment - ab114489 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

ALOX15B / 15 Lipoxygenase 2 Antibody Blocking Peptide - LS-E10000 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ALOX15B / 15 Lipoxygenase 2 Antibody Blocking Peptide - LS-E15420 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ALOX15B / 15 Lipoxygenase 2 Antibody Blocking Peptide - LS-E15419 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ALOX15B / 15 Lipoxygenase 2 Antibody Blocking Peptide - LS-E15430 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ALOX15B / 15 Lipoxygenase 2 Antibody Blocking Peptide - LS-E15431 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human 15-Lipoxygenase 2 Protein - H00000247-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human 15-Lipoxygenase 2 Protein - H00000247-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ALOX15B-Antibody-C-term-Blocking-Peptide - BP9200b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human ALOX15B protein (GST Tag) - orb138166 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human ALOX15B protein - orb138167 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

ALOX15B Blocking Peptide - 33R-5636 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ALOX15B Blocking Peptide - 33R-1552 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ALOX15B Blocking Peptide - 33R-1715 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ALOX15B Blocking Peptide - 33R-5149 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ALOX15B - H00000247-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ALOX15B - H00000247-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ALOX15B - H00000247-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ALOX15B - H00000247-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ALOX15B fusion protein - ag3741 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Arachidonate 15-lipoxygenase, Type B, His-tagged - ALOX15B-580H from Creative Biomart Category Protein Source E. coli.

Recombinant Human ALOX15B, Gly & Pro tagged - ALOX15B-408H from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Human

Recombinant Human ALOX15B, His-GST tagged - ALOX15B-488H from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Human

Recombinant Arachidonate-15-Lipoxygenase, Type B (ALOX15B) - RPB356Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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