| Gene Symbol | ALOX15B |
|---|---|
| Entrez Gene | 247 |
| Alt Symbol | 15-LOX-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | arachidonate 15-lipoxygenase, type B |
| Other Description | 15-LOX-B|15S-lipoxygenase|arachidonate 15-lipoxygenase 2|arachidonate 15-lipoxygenase B|arachidonate 15-lipoxygenase type II|arachidonate 15-lipoxygenase, second type|arachidonate omega(6) lipoxygenase|linoleate 13-lipoxygenase 15-LOb |
| Swissprots | Q8TEV5 Q8TEV3 D3DTR2 Q9UKM4 Q8TEV6 Q8TEV4 Q8IYQ2 O15296 |
| Accessions | AAD37786 CAC34521 EAW90097 EAW90098 EAW90099 EAW90100 EAW90101 EAW90102 O15296 AF468051 AAL76274 AF468052 AAL76275 AF468053 AAL76276 AF468054 AAL76277 AK292779 BAF85468 AK298095 BAG60380 AK300554 BAG62260 BC033294 BC035217 AAH35217 BC063647 AAH63647 BP327830 CA307212 CA405703 DQ891345 ABM82271 EU176579 ABW03380 U78294 AAB61706 NM_001039130 NP_001034219 NM_001039131 NP_001034220 NM_001141 NP_001132 |
| Function | Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells. {ECO:0000269|PubMed:10625675, ECO:0000269|PubMed:11839751, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:16112079, ECO:0000269|PubMed:18067895, ECO:0000269|PubMed:22912809, ECO:0000269|PubMed:24497644}. |
| Subcellular Location | Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus. |
| Tissue Specificity | Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea. {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:11350124, ECO:0000269|PubMed:9177185}. |
| Top Pathways | Arachidonic acid metabolism |