Gene Symbol | NPRL3 |
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Entrez Gene | 8131 |
Alt Symbol | C16orf35, CGTHBA, HS-40, MARE, NPR3, RMD11 |
Species | Human |
Gene Type | protein-coding |
Description | nitrogen permease regulator-like 3 (S. cerevisiae) |
Other Description | -14 gene protein|alpha-globin regulatory element-containing gene protein|conserved gene telomeric to alpha globin cluster|nitrogen permease regulator 3-like protein |
Swissprots | Q1W6H0 Q12980 Q92469 Q4TT56 D3DU40 |
Accessions | ABD95907 CAB06556 CAI94885 CAI94886 CAI95611 CAI95612 CAM13055 EAW85865 EAW85867 EAW85868 Q12980 AK026990 AK090717 BAG52219 AK125420 AK294228 BAH11706 AK298795 BAH12872 AK300736 BAH13336 BC004185 AAH04185 BC012825 AAH12825 BC020392 DA075508 DA258664 DA658076 DC384076 HQ448276 ADQ32756 X90857 CAA62368 XM_011522668 XP_011520970 XM_011522669 XP_011520971 XM_011522670 XP_011520972 XM_011522671 XP_011520973 XM_011522672 XP_011520974 XM_011522673 XP_011520975 XM_011522674 XP_011520976 XM_011522675 XP_011520977 XM_011522676 XP_011520978 XM_011522677 XP_011520979 XM_011522678 XP_011520980 XM_011522679 XP_011520981 XM_011522680 XP_011520982 XM_011522681 XP_011520983 NM_001039476 NP_001034565 NM_001077350 NP_001070818 NM_001243247 NP_001230176 NM_001243248 NP_001230177 NM_001243249 NP_001230178 NM_012075 |
Function | As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC- containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. {ECO:0000269|PubMed:23723238}. |
Tissue Specificity | Widely expressed. |
NPRL3 (L-20) - sc-242062 from Santa Cruz Biotechnology
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NPRL3 (N-17) - sc-242061 from Santa Cruz Biotechnology
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Anti-NPRL3 antibody - ab121346 from Abcam
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Anti-NPRL3 antibody - ab128821 from Abcam
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Anti-NPRL3 antibody - C-terminal - ab194387 from Abcam
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Anti-NPRL3 antibody - N-terminal - ab187388 from Abcam
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NPRL3 Antibody - NBP1-88447 from Novus Biologicals
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NPRL3 Antibody - H00008131-A01 from Novus Biologicals
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NPRL3 Antibody (4E6.) - H00008131-M02 from Novus Biologicals
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Anti-NPRL3 antibody produced in rabbit - HPA011741 from Sigma-Aldrich
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Monoclonal Anti-C16orf35 antibody produced in mouse - SAB1401418 from Sigma-Aldrich
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Anti-Nprl3 antibody produced in goat - SAB2501813 from Sigma-Aldrich
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Nprl3-mouse-Antibody-internal-region-N-Term - AF3659a from Abgent, a WuXi AppTec company
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NPRL3 antibody [N2C1], Internal - GTX118501 from GeneTex
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Nprl3 Antibody - N terminal region (OAEB02521) - OAEB02521 from Aviva Systems Biology
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NPRL3 antibody (FITC) - orb222496 from Biorbyt
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MARE antibody - H00008131-A01 from Acris Antibodies
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MARE antibody - H00008131-M02 from Acris Antibodies
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Anti-NPRL3 Antibody - AC21-2600 from Abcore
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Anti-NPRL3 Antibody (AMCA) - AC21-2600-01 from Abcore
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Anti-NPRL3 Antibody (AP) - AC21-2600-02 from Abcore
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Anti-NPRL3 Antibody (APC) - AC21-2600-03 from Abcore
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Anti-NPRL3 Antibody (APC-Cy5.5) - AC21-2600-04 from Abcore
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Anti-NPRL3 Antibody (APC-Cy7) - AC21-2600-05 from Abcore
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Anti-NPRL3 Antibody (Avidin) - AC21-2600-06 from Abcore
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