| Gene Symbol |
PUS10
|
| Entrez Gene |
150962
|
| Alt Symbol |
CCDC139, DOBI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pseudouridylate synthase 10
|
| Other Description |
coiled-coil domain containing 139|coiled-coil domain-containing protein 139|pseudouridine synthase 10|psi55 synthase|putative tRNA pseudouridine synthase Pus10|tRNA pseudouridine 55 synthase|tRNA pseudouridylate synthase|tRNA-uridine isomerase
|
| Swissprots |
Q3MIT2 Q5JPJ5 Q96MI8
|
| Accessions |
EAX00022 EAX00023 EAX00024 EAX00025 EAX00026 EAX00027 Q3MIT2 AA878516 AK056874 BAB71300 AK291729 BAF84418 AL832208 CAI46123 BC065197 BC101680 AAI01681 BC101706 AAI01707 BC143480 BP354604 XM_006711952 XP_006712015 XM_011532568 XP_011530870 XM_011532569 XP_011530871 XM_011532570 XP_011530872 XM_011532571 XP_011530873 XM_011532572 XP_011530874 XM_011532573 XP_011530875 XM_011532574 XP_011530876 XM_011532575 XP_011530877 XM_011532576 XP_011530878 XM_011532577 XP_011530879 XM_011532578 XP_011530880 NM_144709 NP_653310
|
| Function |
Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death. {ECO:0000269|PubMed:14527409, ECO:0000269|PubMed:19712588, ECO:0000305}.
|
![Western Blot: PUS10 Overexpression Lysate (Adult Normal) [NBL1-14998] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PUS10.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5104_PUS10%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14998-img0002.jpg)