| Gene Symbol | FCER1A |
|---|---|
| Entrez Gene | 2205 |
| Alt Symbol | FCE1A, FcERI |
| Species | Human |
| Gene Type | protein-coding |
| Description | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide |
| Other Description | Fc IgE receptor, alpha polypeptide|Fc epsilon RI alpha-chain|Fc-epsilon RI-alpha|high affinity immunoglobulin epsilon receptor alpha-subunit|high affinity immunoglobulin epsilon receptor subunit alpha|igE Fc receptor subunit alpha|immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide |
| Swissprots | P12319 |
| Accessions | AAA16115 BAB84120 CAA01564 CAA82702 CAN36268 EAW52789 P12319 BC005912 AAH05912 BC015185 BC015195 AAH15195 DQ893131 ABM84057 DQ896411 ABM87410 DQ896467 ABM87466 J03605 AAA36204 X06948 CAA30025 NM_002001 NP_001992 |
| Function | Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Top Pathways | Fc epsilon RI signaling pathway, Asthma, Sphingolipid signaling pathway |