Gene Symbol | PASK |
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Entrez Gene | 23178 |
Alt Symbol | PASKIN, STK37 |
Species | Human |
Gene Type | protein-coding |
Description | PAS domain containing serine/threonine kinase |
Other Description | PAS domain-containing serine/threonine-protein kinase|per-arnt-sim (PAS) domain kinase |
Swissprots | Q96RG2 Q05BE4 Q6GSJ5 Q9UFR7 G5E9F1 Q68DY3 Q86XH6 Q99763 |
Accessions | AAC23506 EAW71236 EAW71237 EAW71238 EAW71239 EAW71240 EAW71241 EAW71242 Q96RG2 AF387103 AAK69752 AK026769 AK056516 AK296945 BAH12460 AK302417 BAH13702 AK302561 BAH13743 AL117400 CAB55901 BC020054 BC043495 AAH43495 BC050565 AAH50565 BC063585 AAH63585 CR749231 CAH18087 D50925 BAA09484 DA104684 U79240 AAB50198 XM_005246991 XP_005247048 XM_011510826 XP_011509128 XM_011510827 XP_011509129 XM_011510828 XP_011509130 XM_011510829 XP_011509131 XM_011510830 XP_011509132 XM_011510831 XP_011509133 XM_011510832 XP_011509134 XM_011510833 XP_011509135 XM_011510834 XP_011509136 XM_011510835 XP_011509137 XR_922893 NM_001252119 NP_001239048 NM_001252120 NP_001239049 NM_001252122 NP_001239051 NM_001252124 NP_001239053 NM_015148 NP_055963 |
Function | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17595531}. Nucleus {ECO:0000269|PubMed:17595531}. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails. |
Tissue Specificity | Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level). |
PASK (C70B2) Rabbit mAb - 3086 from Cell Signaling Technology
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PASK (C-14) - sc-74812 from Santa Cruz Biotechnology
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PASK (G-20) - sc-74815 from Santa Cruz Biotechnology
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Anti-PASK antibody - ab114988 from Abcam
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Anti-PASK antibody - ab115164 from Abcam
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Anti-PASK antibody - ab96398 from Abcam
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Anti-PASK antibody - ab57387 from Abcam
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Anti-PASK antibody [11D8] - ab117952 from Abcam
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Anti-PASK antibody [mAB6] - ab111935 from Abcam
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Anti-PASK antibody - C-terminal - ab154053 from Abcam
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Anti-PAS Kinase / PASK Antibody (aa1273-1323) - LS-C289896 from LifeSpan Bioscience
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Anti-PAS Kinase / PASK Antibody (aa425-475) IHC-plus⢠- LS-B11394 from LifeSpan Bioscience
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Anti-PAS Kinase / PASK Antibody (aa930-1323) - LS-C185923 from LifeSpan Bioscience
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Anti-PAS Kinase / PASK Antibody (clone 8G9) - LS-C114899 from LifeSpan Bioscience
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Anti-PAS Kinase / PASK Antibody (clone 11D8) - LS-C114943 from LifeSpan Bioscience
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Anti-PAS Kinase / PASK Antibody (clone 11G9) - LS-C114950 from LifeSpan Bioscience
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PASK Antibody - NBP2-19704 from Novus Biologicals
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PASK Antibody (6D10) - H00023178-M01 from Novus Biologicals
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PASK Antibody (6B7) - H00023178-M02A from Novus Biologicals
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PASK Antibody - H00023178-A01 from Novus Biologicals
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Anti-PASK antibody produced in rabbit - HPA021079 from Sigma-Aldrich
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Monoclonal Anti-PASK, (N-terminal) antibody produced in mouse - SAB1404957 from Sigma-Aldrich
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Anti-PASK antibody produced in rabbit - HPA016450 from Sigma-Aldrich
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Monoclonal Anti-PASK antibody produced in mouse - WH0023178M1 from Sigma-Aldrich
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Anti-PASK (1256-1270) antibody produced in rabbit - K3515 from Sigma-Aldrich
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