| Gene Symbol |
PASK
|
| Entrez Gene |
23178
|
| Alt Symbol |
PASKIN, STK37
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PAS domain containing serine/threonine kinase
|
| Other Description |
PAS domain-containing serine/threonine-protein kinase|per-arnt-sim (PAS) domain kinase
|
| Swissprots |
Q96RG2 Q05BE4 Q6GSJ5 Q9UFR7 G5E9F1 Q68DY3 Q86XH6 Q99763
|
| Accessions |
AAC23506 EAW71236 EAW71237 EAW71238 EAW71239 EAW71240 EAW71241 EAW71242 Q96RG2 AF387103 AAK69752 AK026769 AK056516 AK296945 BAH12460 AK302417 BAH13702 AK302561 BAH13743 AL117400 CAB55901 BC020054 BC043495 AAH43495 BC050565 AAH50565 BC063585 AAH63585 CR749231 CAH18087 D50925 BAA09484 DA104684 U79240 AAB50198 XM_005246991 XP_005247048 XM_011510826 XP_011509128 XM_011510827 XP_011509129 XM_011510828 XP_011509130 XM_011510829 XP_011509131 XM_011510830 XP_011509132 XM_011510831 XP_011509133 XM_011510832 XP_011509134 XM_011510833 XP_011509135 XM_011510834 XP_011509136 XM_011510835 XP_011509137 XR_922893 NM_001252119 NP_001239048 NM_001252120 NP_001239049 NM_001252122 NP_001239051 NM_001252124 NP_001239053 NM_015148 NP_055963
|
| Function |
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17595531}. Nucleus {ECO:0000269|PubMed:17595531}. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.
|
| Tissue Specificity |
Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).
|