| Gene Symbol |
KRTAP10-8
|
| Entrez Gene |
386681
|
| Alt Symbol |
KAP10.8, KRTAP18-8, KRTAP18.8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin associated protein 10-8
|
| Other Description |
high sulfur keratin-associated protein 10.8|keratin associated protein 18-8|keratin-associated protein 10-8|keratin-associated protein 10.8|keratin-associated protein 18-8|keratin-associated protein 18.8
|
| Swissprots |
A0JNW4 P60410
|
| Accessions |
EAX09412 P60410 AB076355 BAD01542 BC127016 AAI27017 NM_198695 NP_941968
|
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
|
| Tissue Specificity |
Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
|