Gene Symbol | KRTAP10-8 |
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Entrez Gene | 386681 |
Alt Symbol | KAP10.8, KRTAP18-8, KRTAP18.8 |
Species | Human |
Gene Type | protein-coding |
Description | keratin associated protein 10-8 |
Other Description | high sulfur keratin-associated protein 10.8|keratin associated protein 18-8|keratin-associated protein 10-8|keratin-associated protein 10.8|keratin-associated protein 18-8|keratin-associated protein 18.8 |
Swissprots | A0JNW4 P60410 |
Accessions | EAX09412 P60410 AB076355 BAD01542 BC127016 AAI27017 NM_198695 NP_941968 |
Function | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. |
Tissue Specificity | Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}. |
KRTAP10-8 CRISPR/Cas9 KO Plasmid (h) - sc-415731 from Santa Cruz Biotechnology
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KRTAP10-8 HDR Plasmid (h) - sc-415731-HDR from Santa Cruz Biotechnology
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KRTAP10-8 Double Nickase Plasmid (h) - sc-415731-NIC from Santa Cruz Biotechnology
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KRTAP10-8 Double Nickase Plasmid (h2) - sc-415731-NIC-2 from Santa Cruz Biotechnology
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KRTAP10-8 CRISPR Activation Plasmid (h) - sc-415731-ACT from Santa Cruz Biotechnology
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KRTAP10-8 CRISPR Activation Plasmid (h2) - sc-415731-ACT-2 from Santa Cruz Biotechnology
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KRTAP10-8 Lentiviral Activation Particles (h) - sc-415731-LAC from Santa Cruz Biotechnology
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KRTAP10-8 Lentiviral Activation Particles (h2) - sc-415731-LAC-2 from Santa Cruz Biotechnology
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KRTAP10-8 siRNA (h) - sc-91508 from Santa Cruz Biotechnology
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KRTAP10-8 shRNA Plasmid (h) - sc-91508-SH from Santa Cruz Biotechnology
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KRTAP10-8 shRNA (h) Lentiviral Particles - sc-91508-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN11424 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11424 from Sigma-Aldrich
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KRTAP10-8 siRNA (Human) - CRJ7717 from Cohesion Biosciences
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Human KRTAP10-8 siRNA - orb278218 from Biorbyt
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KRTAP10-8 shRNA Plasmid (Human) - CHJ7717 from Cohesion Biosciences
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KRTAP10-8 miRNA 3'UTR clone - MiUTR4H-TG04938 from Creative biogene
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