| Gene Symbol | DAD1 |
|---|---|
| Entrez Gene | 1603 |
| Alt Symbol | OST2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | defender against cell death 1 |
| Other Description | DAD-1|dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1|oligosaccharyl transferase subunit DAD1|oligosaccharyltransferase 2 homolog|oligosaccharyltransferase subunit 2 (non-catalytic) |
| Swissprots | P61803 D3DS25 Q6FGA3 |
| Accessions | AAB58540 AAO74827 EAW66252 EAW66253 P61803 AK223129 BAD96849 BC007403 AAH07403 BC009798 AAH09798 BC038575 BP198316 CR407682 CAG28610 CR542204 CAG47001 D15057 BAA03650 DQ892868 ABM83794 DQ896117 ABM87116 NM_001344 NP_001335 |
| Function | Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Top Pathways | N-Glycan biosynthesis, Protein processing in endoplasmic reticulum |