Gene Symbol | DENND2A |
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Entrez Gene | 27147 |
Alt Symbol | FAM31D, KIAA1277 |
Species | Human |
Gene Type | protein-coding |
Description | DENN/MADD domain containing 2A |
Other Description | DENN domain-containing protein 2A |
Swissprots | Q86XY0 Q1RMD5 C9JUI3 Q9ULE3 |
Accessions | EAW83954 Q9ULE3 AB033103 BAA86591 AK290056 BAF82745 AK297959 BAG60271 BC049193 AAH49193 BC115004 AAI15005 BC132875 AAI32876 BC144190 DA401015 XM_005249976 XP_005250033 XM_005249977 XP_005250034 XM_005249978 XP_005250035 XM_005249979 XP_005250036 XM_011516052 XP_011514354 XM_011516053 XP_011514355 XM_011516054 XP_011514356 XR_927456 NM_015689 NP_056504 |
Function | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269|PubMed:20937701}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20937701}. Note=Associated with actin filaments. |
DENND2A CRISPR/Cas9 KO Plasmid (h) - sc-411968 from Santa Cruz Biotechnology
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DENND2A HDR Plasmid (h) - sc-411968-HDR from Santa Cruz Biotechnology
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DENND2A Double Nickase Plasmid (h) - sc-411968-NIC from Santa Cruz Biotechnology
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DENND2A Double Nickase Plasmid (h2) - sc-411968-NIC-2 from Santa Cruz Biotechnology
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DENND2A CRISPR Activation Plasmid (h) - sc-411968-ACT from Santa Cruz Biotechnology
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DENND2A CRISPR Activation Plasmid (h2) - sc-411968-ACT-2 from Santa Cruz Biotechnology
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DENND2A Lentiviral Activation Particles (h) - sc-411968-LAC from Santa Cruz Biotechnology
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DENND2A Lentiviral Activation Particles (h2) - sc-411968-LAC-2 from Santa Cruz Biotechnology
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DENND2A siRNA (h) - sc-89828 from Santa Cruz Biotechnology
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DENND2A shRNA Plasmid (h) - sc-89828-SH from Santa Cruz Biotechnology
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DENND2A shRNA (h) Lentiviral Particles - sc-89828-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7138 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7138 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02611 from Sigma-Aldrich
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DENND2A siRNA (Human) - CRH8993 from Cohesion Biosciences
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DENND2A - MBS8235235 from MyBioSource
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shRNA set against Human DENND2A (NM_015689.3) - SHH277033 from Creative biogene
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shRNA set against Human DENND2A(NM_015689.3) - SHH001307 from Creative biogene
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Human DENND2A siRNA - orb269495 from Biorbyt
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DENND2A shRNA Plasmid (Human) - CHH8993 from Cohesion Biosciences
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DENND2A miRNA 3'UTR clone - MiUTR1H-02772 from Creative biogene
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