ATM

Gene Symbol	ATM
Entrez Gene	472
Alt Symbol	AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Species	Human
Gene Type	protein-coding
Description	ATM serine/threonine kinase
Other Description	A-T mutated|AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated|serine-protein kinase ATM
Swissprots	Q9UCX7 Q93007 Q9NP02 Q12758 B2RNX5 Q13315 O15429 Q16551
Accessions	AAB38309 AAB38310 AAB65827 AAC51298 AAO26044 EAW67108 EAW67109 EAW67110 EAW67111 EAW67112 EAW67113 EAW67114 EAW67115 Q13315 AB209133 BAD92370 AF035326 AAM09293 AF035327 AAM09294 AF035328 AAM09295 AK299843 BAG61705 BC007023 BC022306 BC022307 BC061584 AAH61584 BC137169 AAI37170 BC152385 AAI52386 BC152389 AAI52390 BT006764 AAP35410 CR749436 CAH18274 HM437232 ADN43064 KF704396 U26455 AAA86520 U33841 AAC50289 U67093 X91196 CAA62603 Y08455 CAA69711 XM_005271561 XP_005271618 XM_005271562 XP_005271619 XM_006718843 XP_006718906 XM_006718845 XP_006718908 XM_011542840 XP_011541142 XM_011542841 XP_011541143 XM_011542842 XP_011541144 XM_011542843 XP_011541145 XM_011542844 XP_011541146 XM_011542845 XP_011541147 XM_011542846 XP_011541148 XM_011542847 XP_011541149 NM_000051 NP_000042 NM_138292 NM_138293
Function	Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as
Subcellular Location	Nucleus. Cytoplasmic vesicle. Note=Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
Tissue Specificity	Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Top Pathways	Apoptosis, Cell cycle, p53 signaling pathway, HTLV-I infection, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ATM (phospho S1981) peptide - ab13767 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ATM (phospho S1981) peptide - ab95037 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ATM peptide - ab170988 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ATM peptide - ab90257 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human ATM full length protein - ab131739 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human ATM peptide - ab116499 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human ATM protein fragment - ab157923 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ATM Antibody Blocking Peptide - LS-E30276 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ATM Antibody Blocking Peptide - LS-E7403 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ATM Protein - H00000472-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ATM Protein - H00000472-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ATM Peptide - P1637 from Novus Biologicals Category Peptide Species Human

Phospho-ATMS1981-Antibody-Blocking-peptide - BP3504a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

ATM peptide - orb218793 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

ATM (phospho-Ser1981) Blocking Peptide - abx064122 from Abbexa Category Peptide Species Human, Mouse, Rat

ATM (phospho-Ser1987) Blocking Peptide - abx064123 from Abbexa Category Peptide Species Human, Mouse, Rat

ATM Blocking Peptide - abx064124 from Abbexa Category Peptide Species Human, Mouse, Rat

ATM - H00000472-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ATM - H00000472-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ATM - H00000472-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ATM - H00000472-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ATM Control Peptide - AP30094CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

ATM Peptide - 3945P from ProSci Category Peptide Species Human

ATM fusion protein - Ag15123 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PKG Species Human

ATM Peptide - 350520 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

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