ATM

Gene Symbol ATM
Entrez Gene 472
Alt Symbol AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Species Human
Gene Type protein-coding
Description ATM serine/threonine kinase
Other Description A-T mutated|AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated|serine-protein kinase ATM
Swissprots Q9UCX7 Q93007 Q9NP02 Q12758 B2RNX5 Q13315 O15429 Q16551
Accessions AAB38309 AAB38310 AAB65827 AAC51298 AAO26044 EAW67108 EAW67109 EAW67110 EAW67111 EAW67112 EAW67113 EAW67114 EAW67115 Q13315 AB209133 BAD92370 AF035326 AAM09293 AF035327 AAM09294 AF035328 AAM09295 AK299843 BAG61705 BC007023 BC022306 BC022307 BC061584 AAH61584 BC137169 AAI37170 BC152385 AAI52386 BC152389 AAI52390 BT006764 AAP35410 CR749436 CAH18274 HM437232 ADN43064 KF704396 U26455 AAA86520 U33841 AAC50289 U67093 X91196 CAA62603 Y08455 CAA69711 XM_005271561 XP_005271618 XM_005271562 XP_005271619 XM_006718843 XP_006718906 XM_006718845 XP_006718908 XM_011542840 XP_011541142 XM_011542841 XP_011541143 XM_011542842 XP_011541144 XM_011542843 XP_011541145 XM_011542844 XP_011541146 XM_011542845 XP_011541147 XM_011542846 XP_011541148 XM_011542847 XP_011541149 NM_000051 NP_000042 NM_138292 NM_138293
Function Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as
Subcellular Location Nucleus. Cytoplasmic vesicle. Note=Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
Tissue Specificity Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Top Pathways Apoptosis, Cell cycle, p53 signaling pathway, HTLV-I infection, MicroRNAs in cancer

Phospho-(Ser/Thr) ATM/ATR Substrate (4F7) Rabbit mAb - 2909 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 4F7
Western blot analysis of extracts from HeLa cells, untreated or treated with γ-irradiation, using Phospho-(Ser/Thr) ATM/ATR Substrate (4F7) Rabbit mAb.

Phospho-ATM (Ser1981) (D6H9) Rabbit mAb - 5883 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6H9
Western blot analysis of extracts from 293 cells, untreated or UV-treated (100 mJ, 4 hr recovery), using Phospho-ATM (Ser1981) (D6H9) Rabbit mAb (upper) or ATM (D2E2) Rabbit mAb #2873 (lower).

Phospho-ATM (Ser1981) (10H11.E12) Mouse mAb - 4526 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Mouse
Clonality Monoclonal
Clone 10H11.E12
Western blot analysis of extracts from M059J cells, untreated, treated with doxorubicin, or treated with bleomycin, using Phospho-ATM (Ser1981) (10H11.E12) Mouse mAb.

Phospho-ATM (Ser1981) (D25E5) Rabbit mAb - 13050 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D25E5
Western blot analysis of extracts from HCT 116 cells, untreated (-) or treated with neocarzinostatin (NCS 10 μM, 1 hr; +), using Phospho-ATM (Ser1981) (D25E5) Rabbit mAb (upper) and ATM (D2E2) Rabbit mAb #2873 (lower).

ATM (D2E2) Rabbit mAb - 2873 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2E2
Western blot analysis of extracts of HeLa, NCCIT and PYS2 cells using ATM (D2E2) Rabbit mAb.

Phospho-ATM/ATR Substrate Motif [(pS/pT) QG] MultiMab™ Rabbit mAb mix - 6966 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated (-) or UV-treated (+, 50 mJ/cm 2 , 2 hr), using

Phospho-(Ser/Thr) ATM/ATR Substrate Antibody - 2851 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, untreated or UV-treated, using Phospho-(Ser/Thr) ATM/ATR Substrate Antibody.

Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) MultiMab™ Rabbit mAb mix - 9607 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated (-) or UV-treated (2 hr; +), using Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) MultiMab™ Rabbit mAb mix. Western blot was imaged using Odyssey ® Infrared Imaging System (LI-COR ® Biotechnologies).

Atm (H-248) - sc-7230 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Atm expression in G-361 whole cell lysate. Antibodies tested include Atm (N-17): sc-1213 (A), Atm (Q-19): sc-7129 (B) and Atm (H-248): sc-7230 (C).

Atm (1A1) - sc-73615 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Atm (1A1): sc-73615. Western blot analysis of Atm expression in SK-N-SH whole cell lysate.

Atm (G-12) - sc-377293 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Atm (G-12): sc-377293. Western blot analysis of Atm expression in A-431 nuclear extract (A) and SK-MEL-28 (B) whole cell lysate.

Atm (N-17) - sc-1213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Atm expression in G-361 whole cell lysate. Antibodies tested include Atm (N-17): sc-1213 (A), Atm (Q-19): sc-7129 (B) and Atm (H-248): sc-7230 (C).

Atm (R-18) - sc-7128 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Atm (R-18): sc-7128. Western blot analysis of human recombinant Atm fusion protein.

Atm (Q-19) - sc-7129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Atm (Q-19): sc-7129. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

Atm (K-19) - sc-1214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Atm (ATM 11G12) - sc-53173 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Atm (ATM 11G12): sc-53173. Western blot analysis of Atm expression in SK-N-SH whole cell lysate.

Atm (C-20) - sc-1212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Atm (H-280) - sc-15392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Atm (H-300) - sc-28881 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Atm (H-300): sc-28881. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing nuclear staining of glandular cells.

Atm (2C1) - sc-23921 from Santa Cruz Biotechnology

Prices $303.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Atm (2C1): sc-23921. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

Atm (1B10) - sc-135663 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Atm (1B10): sc-135663. Western blot analysis of Atm expression in HeLa (A), Jurkat (B), 293T (C), Raji (D) and A-431 (E) whole cell lysates.

Atm (5C2) - sc-23922 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Atm (5C2): sc-23922. Western blot analysis of Atm expression in HeLa (A) and G-361 (B) whole cell lysates.

p-Atm (10H11.E12) - sc-47739 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-Atm (10H11.E12): sc-47739. Western blot analysis of Atm phosphorylation in lambda protein phosphatase treated (B,D) and untreated (A,C) HeLa whole cell lysates. Antibodies tested include p-Atm (10H11.E12): sc-47739 (A,B) and Atm (5C2): sc-23922 (C,D).

Anti-ATM (phospho S1981) antibody - ab79891 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ATM (phospho S1981) antibody (ab79891) at 1 µg/mlLane 1 : Irradiated Hela (Control for ATM phospho S1981) Whole Cell Lysate Lane 2 : Irradiated Hela (Control for ATM phospho S1981) Whole Cell Lysate with Human ATM peptide (ab116499) at 1 µg/mlLane 3 : Irradiated Hela (Control for ATM phospho S1981) Whole Cell Lysate with ATM (phospho S1981) peptide (ab95037) at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-ATM (phospho S1981) antibody - ab194865 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ATM (phospho S1981) antibody (ab194865) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : HeLa cell extract treated with UV
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