CDC42

Gene Symbol	CDC42
Entrez Gene	998
Alt Symbol	CDC42Hs, G25K
Species	Human
Gene Type	protein-coding
Description	cell division cycle 42
Other Description	G25K GTP-binding protein|GTP binding protein, 25kDa|GTP-binding protein, 25kD|cell division control protein 42 homolog|dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))|dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))|growth-regulating protein|small GTP binding protein CDC42
Swissprots	Q9UDI2 Q7L8R5 P60953 P21181 P25763
Accessions	AAT70721 CAE93985 CAI61729 EAW95002 EAW95003 EAW95004 EAW95005 EAW95006 EAW95007 EAW95008 EAW95009 P60953 AF498962 AAM21109 AF498963 AAM21110 AK297465 BAG59887 AK303994 BAG64911 AK311375 AK316449 BAH14820 AL121734 CAB57325 AL121735 CAB57326 AL121736 CAB57327 AL121737 CAB57328 BC002711 AAH02711 BC003682 AAH03682 BC018266 AAH18266 BC018622 BM684474 BP871988 DQ596760 DQ891195 ABM82121 DQ894377 ABM85303 M35543 AAA52494 M57298 AAA52592 NM_001039802 NP_001034891 NM_001791 NP_001782 NM_044472 NP_426359
Function	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:17038317}.
Subcellular Location	Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.
Top Pathways	Adherens junction, Endocytosis, Rap1 signaling pathway, Chemokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CDC42 CRISPR/Cas9 KO Plasmid (h) - sc-418353 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CDC42 HDR Plasmid (h) - sc-418353-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CDC42 Double Nickase Plasmid (h) - sc-418353-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CDC42 Double Nickase Plasmid (h2) - sc-418353-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CDC42 CRISPR Activation Plasmid (h) - sc-418353-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CDC42 CRISPR Activation Plasmid (h2) - sc-418353-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CDC42 Lentiviral Activation Particles (h) - sc-418353-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CDC42 Lentiviral Activation Particles (h2) - sc-418353-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cdc42 siRNA (h) - sc-29256 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cdc42 shRNA Plasmid (h) - sc-29256-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cdc42 shRNA (h) Lentiviral Particles - sc-29256-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CDC42 RNAi - H00000998-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CDC42 RNAi - H00000998-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU117241 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU112491 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5782 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5782 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09328 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09328

CDC42 siRNA (Human) - CRH0712 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CDC42 - MBS8237145 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CDC42 (NM_001791.3) - SHH259809 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CDC42(NM_001039802.1) - SHG161349 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CDC42(NM_001791.3) - SHG161497 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CDC42(NM_044472.2) - SHG161935 from Creative biogene Category siRNA Species Reactivities Human

Human CDC42 siRNA - orb261214 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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