CDC42

Gene Symbol CDC42
Entrez Gene 998
Alt Symbol CDC42Hs, G25K
Species Human
Gene Type protein-coding
Description cell division cycle 42
Other Description G25K GTP-binding protein|GTP binding protein, 25kDa|GTP-binding protein, 25kD|cell division control protein 42 homolog|dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))|dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))|growth-regulating protein|small GTP binding protein CDC42
Swissprots Q9UDI2 Q7L8R5 P60953 P21181 P25763
Accessions AAT70721 CAE93985 CAI61729 EAW95002 EAW95003 EAW95004 EAW95005 EAW95006 EAW95007 EAW95008 EAW95009 P60953 AF498962 AAM21109 AF498963 AAM21110 AK297465 BAG59887 AK303994 BAG64911 AK311375 AK316449 BAH14820 AL121734 CAB57325 AL121735 CAB57326 AL121736 CAB57327 AL121737 CAB57328 BC002711 AAH02711 BC003682 AAH03682 BC018266 AAH18266 BC018622 BM684474 BP871988 DQ596760 DQ891195 ABM82121 DQ894377 ABM85303 M35543 AAA52494 M57298 AAA52592 NM_001039802 NP_001034891 NM_001791 NP_001782 NM_044472 NP_426359
Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:17038317}.
Subcellular Location Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.
Top Pathways Adherens junction, Endocytosis, Rap1 signaling pathway, Chemokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD)

Phospho-Rac1/cdc42 (Ser71) Antibody - 2461 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of A431 cell extracts, untreated (-) or EGF treated (+), using Phospho-Rac1/cdc42 (Ser71) Antibody (upper) or Rac1/Cdc42 Antibody #4651 (lower).

Cdc42 (11A11) Rabbit mAb - 2466 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 11A11
Western blot analysis of extracts from various cell lysates, using Cdc42 (11A11) Rabbit mAb.

Rac1/Cdc42 Antibody - 4651 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Rac1/Cdc42 Antibody.

Cdc42 Antibody - 2462 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of HEK293, HT29, A431, PL45, THP1, Jurkat, NIH/3T3, L929, C6, H-4-II-B and BAEC cells, using Cdc42 Antibody.

Cdc42 (B-8) - sc-8401 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc42 (B-8): sc-8401. Western blot analysis of Cdc42 expression in Jurkat (A) and 3611-RF (B) whole cell lysates.

Cdc42 (B-9) - sc-390210 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc42 (B-9): sc-390210. Western blot analysis of Cdc42 expression in C. elegans whole cell lysate.

Cdc42 (C-20) - sc-6083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cdc42 (C-20): sc-6083. Western blot analysis of Cdc42 expression in non-transfected 293T: sc-117752 (A), human Cdc42 transfected 293T: sc-110467 (B) and Jurkat (C) whole cell lysates.

Cdc42 (L-13) - sc-34315 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cdc42 (R-12) - sc-34314 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cdc42 (P1) - sc-87 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cdc42 (P1): sc-87. Western blot analysis of Cdc42 expression in Jurkat (A), 3611-RF (B), HeLa (C) and NIH/3T3 (D) whole cell lysates.

Anti-CDC42 antibody - ab64533 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CDC42 antibody (ab64533) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 4 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 5 : U2OS (Human osteosarcoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CDC42 antibody - ab155940 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of A431 cells, labeling CDC42 with ab155940 at 1/20 dilution. F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is also shown.

Anti-CDC42 antibody - ab66573 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CDC42 antibody (ab66573) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 4 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 5 : U2OS (Human osteosarcoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-CDC42 antibody - ab106374 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
Lane 1 : Anti-CDC42 antibody (ab106374) at 0.5 µg/mlLane 2 : Anti-CDC42 antibody (ab106374) at 1 µg/mlLane 1 : Human brain tissue lysateLane 2 : Human brain tissue lysateLysates/proteins at 15 µg per lane.

Anti-CDC42 antibody - ab176539 from Abcam

Prices $376.00
Sizes 100 µl
Host Chicken
Clonality Polyclonal
Anti-CDC42 antibody (ab176539) at 1/100 dilution + HepG2 whole cell lysate

Anti-CDC42 antibody [1] - ab80653 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1
Anti-CDC42 antibody [1] (ab80653) at 1/1000 dilution + Recombinant CDC42 protein

Anti-CDC42 antibody [EPR15620] - ab187643 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15620
All lanes : Anti-CDC42 antibody [EPR15620] (ab187643) at 1/20000 dilutionLane 1 : Jurkat cell lysateLane 2 : HT-29 cell lysateLane 3 : HeLa cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-CDC42 antibody [M152] - ab41429 from Abcam

Prices $392.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone M152
Lanes 1 & 3 : Anti-CDC42 antibody [M152] (ab41429) at 1/125 dilutionLanes 2 & 4 : Anti-CDC42 antibody [M152] (ab41429) at 1/500 dilutionLane 1 : human jurkat cellsLane 2 : human jurkat cellsLane 3 : mouse brainLane 4 : mouse brainLysates/proteins at 20 µg per lane.

Anti-CDC42 antibody - N-terminal - ab177407 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-CDC42 antibody - N-terminal (ab177407) at 0.5 µg/mlLane 2 : Anti-CDC42 antibody - N-terminal (ab177407) at 1 µg/mlLane 1 : Human brain tissue lysateLane 2 : Human brain tissue lysate

Anti-CDC42 Antibody - LS-C48181 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CDC42 Antibody (Lys135) - LS-C22025 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDC42 Antibody (aa1-191) - LS-C78970 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-CDC42 Antibody (aa141-154) - LS-C63194 from LifeSpan Bioscience

Prices $230.00, $330.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDC42 Antibody (C-Terminus) - LS-C153280 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CDC42 Antibody (aa121-138) - LS-C172250 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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