Gene Symbol | ARHGAP15 |
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Entrez Gene | 55843 |
Alt Symbol | BM046 |
Species | Human |
Gene Type | protein-coding |
Description | Rho GTPase activating protein 15 |
Other Description | rho GTPase-activating protein 15|rho-type GTPase-activating protein 15 |
Swissprots | Q8IXX1 Q584N9 Q9NRL8 Q9NZ77 Q53SX9 Q9NZ91 Q53QZ3 Q6PJE6 Q53R36 Q53RD7 Q53RT6 Q86WP1 |
Accessions | AAX82009 AAX93158 AAX93160 AAX93245 AAY14811 AAY24215 EAX11587 EAX11588 EAX11589 EAX11590 Q53QZ3 AF212222 AAF87324 AF217507 AAF67618 AF217522 AAF67633 AK226014 AK303490 BAG64525 AK308219 AY219338 AAO34684 BC016701 AAH16701 BC038976 AAH38976 BP299206 XM_005263714 XP_005263771 XM_006712632 XP_006712695 XM_011511479 XP_011509781 XM_011511480 XP_011509782 XM_011511481 XP_011509783 XM_011511482 XP_011509784 XM_011511483 XP_011509785 XM_011511484 XP_011509786 NM_018460 NP_060930 |
Function | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12650940}. Membrane {ECO:0000269|PubMed:12650940}; Peripheral membrane protein {ECO:0000269|PubMed:12650940}. |
Tissue Specificity | Expressed in lung, liver and lymphoid cells. {ECO:0000269|PubMed:12650940}. |
ARHGAP15 CRISPR/Cas9 KO Plasmid (h) - sc-412624 from Santa Cruz Biotechnology
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ARHGAP15 HDR Plasmid (h) - sc-412624-HDR from Santa Cruz Biotechnology
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ARHGAP15 Double Nickase Plasmid (h) - sc-412624-NIC from Santa Cruz Biotechnology
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ARHGAP15 Double Nickase Plasmid (h2) - sc-412624-NIC-2 from Santa Cruz Biotechnology
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ARHGAP15 CRISPR Activation Plasmid (h) - sc-412624-ACT from Santa Cruz Biotechnology
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ARHGAP15 CRISPR Activation Plasmid (h2) - sc-412624-ACT-2 from Santa Cruz Biotechnology
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ARHGAP15 Lentiviral Activation Particles (h) - sc-412624-LAC from Santa Cruz Biotechnology
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ARHGAP15 Lentiviral Activation Particles (h2) - sc-412624-LAC-2 from Santa Cruz Biotechnology
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ARHGAP15 siRNA (h) - sc-94966 from Santa Cruz Biotechnology
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ARHGAP15 shRNA Plasmid (h) - sc-94966-SH from Santa Cruz Biotechnology
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ARHGAP15 shRNA (h) Lentiviral Particles - sc-94966-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU033281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3410 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3410 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00807 from Sigma-Aldrich
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ARHGAP15 siRNA (Human) - CRJ0964 from Cohesion Biosciences
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ARHGAP15 - MBS8208219 from MyBioSource
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shRNA set against Human ARHGAP15 (NM_018460.3) - SHH239330 from Creative biogene
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ARHGAP15 shRNA Plasmid (Human) - CHJ0964 from Cohesion Biosciences
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ARHGAP15 miRNA 3'UTR clone - MiUTR3H-11324 from Creative biogene
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